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  • Human Anti-MST1R Recombinant Antibody (clone Ch07F01 C102S); Fab Fragment

Human Anti-MST1R Recombinant Antibody (clone Ch07F01 C102S); Fab Fragment (CAT#: HPAB-J0190-YC-F(E))

Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d'Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON. It has shown that antibodies 07F01, 12B11, 17F06, 18H09 and 29B06 each inhibited MSP induced ERK phosphorylation in T47D cells, while only antibodies 07F01, 18H09 and 29B06 each blocked MSP binding to hRON SEMA+PSI in the neutralization assay. This suggests that antibodies 12B11 and 17F06 do not neutralize binding of MSP to the hRON SEMA+PSI domain, neutralize binding of MSP to RON in the context of the full RON extracellular domain, or function by a mechanism other than blocking MSP binding to RON.

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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/44_E6_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_5.jpg
Figure 3 Colon
Figure 3 Colon
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_3.jpg
Figure 4 Liver
Figure 4 Liver
(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_4.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_9_5.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_6_6.jpg
Figure 7 Skin
Figure 7 Skin
(Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_1.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
Figure 9 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164078-MST1R

Specifications

  • Immunogen
  • Recombinant human RON extracellular domain (hRON-ECD)
  • Host Species
  • Human
  • Derivation
  • Chimeric (mouse/human)
  • Type
  • Chimeric (mouse/human) Fab
  • Specificity
  • Human MST1R
  • Species Reactivity
  • Human
  • Clone
  • Ch07F01 C102S
  • Applications
  • ELISA, Neut, FuncS

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Macrophage Stimulating 1 Receptor; PTK8 Protein Tyrosine Kinase 8; C-Met-Related Tyrosine Kinase; MSP Receptor; EC 2.7.10.1; P185-Ron; CDw136; PTK8

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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CAT Product Name Application Type
TAB-184 Anti-Human RON Recombinant Antibody (Narnatumab) FuncS, IF, Neut, ELISA, FC, IP, ICC IgG1 - kappa
TAB-332CT-S(P) Anti-Human RON Recombinant Antibody scFv Fragment (TAB-332CT-S(P)) WB, ELISA, FC Human antibody
TAB-333CT-S(P) Human Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-333CT-S(P)) WB, ELISA, FC, IP Human scFv
TAB-332CT-F(E) Anti-Human RON Recombinant Antibody Fab Fragment (TAB-332CT-F(E)) WB, ELISA, FC Human antibody
TAB-333CT-F(E) Human Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-333CT-F(E)) WB, ELISA, FC, IP Human Fab

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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