Mouse Anti-MST1R Recombinant Antibody (clone 07F01)

Name: Mouse Anti-MST1R Recombinant Antibody (clone 07F01)
SKU: HPAB-687-FY
Rating: 5 (1 reviews)

CAT#: HPAB-687-FY

This product is a recombinant antibody that recognizes MST1R. The monoclonal antibody 07F01 reacts with the epitope of MST1R. antibody 07F01 inhibits MSP induced ERK phosphorylation in T47D cells. This antibody can be used to treat certain forms of cancer that are associated with activation of RON.

Published Data Gene Expression

Neut

Figure 1 Anti-RON antibodies potently inhibit MSP binding to RON.

Neutralization of ligand binding.

Inhib

Figure 2 Anti-RON antibodies potently inhibit MSP binding to RON.

Anti-RON antibodies inhibit MSP-induced signaling in T47D Cells.

Inhib

Figure 3 Anti-RON mAbs inhibit RON receptor-driven tumorigenesis.

Proprietary Directed Complemented (DC) breast tumor model driven by WT RON.

Cyt

Figure 4 07F01 decreases proliferation (Ki67) and increases apoptosis (TUNEL) in WT RON DC tumors.

ELISA

Figure 5 Pharmacokinetic parameters of 29B06 and 07F01.

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Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/44_E6_1_selected.jpg

Normal Tissue Figure 2 Cerebral cortex

Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_5.jpg

Normal Tissue Figure 3 Colon

Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_3.jpg

Normal Tissue Figure 4 Liver

Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_4.jpg

Normal Tissue Figure 5 Kidney

Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_9_5.jpg

Normal Tissue Figure 6 Testis

Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_6_6.jpg

Normal Tissue Figure 7 Skin

Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_1.jpg

Normal Tissue Figure 8 Lymph node

Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_8_8.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164078-MST1R

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Specifications

Host Species
Mouse

Type
Mouse IgG

Specificity
Human MST1R

Species Reactivity
Human

Clone
07F01

Applications
Neut, Inhib, Cyt, ELISA

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

Application Notes
The MST1R antibody has been reported in applications of Neutralization, Inhibition, Cytotoxicity, Enzyme-linked Immunosorbent Assay.

Target

Alternative Names
RON; PTK8; CD136; NPCA3; CDw136

Gene ID
4486

UniProt ID
Q04912

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-687-FY.pdf

MSDS

MSDS - HPAB-687-FY.pdf

COA

Certificate of Analysis Lookup

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