Mouse Anti-MST1R Recombinant Antibody (clone 17F06)
CAT#: HPAB-J0189-YC
The monoclonal antibody that binds and inhibits activation of human RON is disclosed. The antibodies can be used to treat certain forms of cancer that are associated with the activation of RON. It has shown that antibody 17F06 inhibits MSP induced ERK phosphorylation in T47D cells in the neutralization assay. This suggests that antibody 17F06 neutralized the binding of MSP to RON in the context of the full RON extracellular domain.
Published Data
Gene Expression
Neut
Figure 1 shows dose-response curves for inhibition of the MSP-RON binding interaction by antibodies 17F06 (▴).
Inhib
Figure 2 showing dose-response curves for inhibition of MSP-dependent phosphorylation of ERK by antibodies 17F06 (▴).
ELISA
Figure 3 plotting antigen binding by the indicated concentrations of various humanized 2B9 antibodies, as determined by an ELISA.
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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/44_E6_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_6_6.jpg
Normal Tissue
Figure 7 Skin
Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_1.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164078-MST1R
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Specifications
- Immunogen
- Recombinant human RON extracellular domain (hRON-ECD)
- Host Species
- Mouse
- Type
- Mouse IgG2a, λ
- Specificity
- Human MST1R
- Species Reactivity
- Human
- Clone
- 17F06
- Applications
- Neut, ELISA, FuncS, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-Linked Immunosorbent Assay, Functional Assay, Inhibition and Neutralization.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- CAT
- Product Name
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| TAB-331CT | Anti-Human RON Recombinant Antibody (TAB-331CT) | WB, ELISA, FC | |
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| TAB-335CT | Mouse Anti-MST1R Recombinant Antibody (TAB-335CT) | WB, ELISA, FC, IP | Mouse IgG2a, κ |
| TAB-331CT-F(E) | Anti-Human RON Recombinant Antibody Fab Fragment (TAB-331CT-F(E)) | WB, ELISA, FC | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-332CT | Anti-Human RON Recombinant Antibody (TAB-332CT) | WB, ELISA, FC | Human antibody |
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