Mouse Anti-MST1R Recombinant Antibody (clone 17F06) (CAT#: HPAB-J0189-YC)
The monoclonal antibody that binds and inhibits activation of human RON is disclosed. The antibodies can be used to treat certain forms of cancer that are associated with the activation of RON. It has shown that antibody 17F06 inhibits MSP induced ERK phosphorylation in T47D cells in the neutralization assay. This suggests that antibody 17F06 neutralized the binding of MSP to RON in the context of the full RON extracellular domain.
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Neut
Figure 1 shows dose-response curves for inhibition of the MSP-RON binding interaction by antibodies 17F06 (▴).
Inhib
Figure 2 showing dose-response curves for inhibition of MSP-dependent phosphorylation of ERK by antibodies 17F06 (▴).
ELISA
Figure 3 plotting antigen binding by the indicated concentrations of various humanized 2B9 antibodies, as determined by an ELISA.
Specifications
- Immunogen
- Recombinant human RON extracellular domain (hRON-ECD)
- Host Species
- Mouse
- Type
- Mouse IgG2a, λ
- Specificity
- Human MST1R
- Species Reactivity
- Human
- Clone
- 17F06
- Applications
- Neut, ELISA, FuncS, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-Linked Immunosorbent Assay, Functional Assay, Inhibition and Neutralization.
Target
- Alternative Names
- Macrophage Stimulating 1 Receptor; PTK8 Protein Tyrosine Kinase 8; C-Met-Related Tyrosine Kinase; MSP Receptor; EC 2.7.10.1; P185-Ron; CDw136; PTK8
- Gene ID
- 4486
- UniProt ID
- Q04912
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-184 | Anti-Human RON Recombinant Antibody (Narnatumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
| TAB-332CT | Anti-Human RON Recombinant Antibody (TAB-332CT) | WB, ELISA, FC | Human antibody |
| TAB-333CT | Human Anti-MST1R Recombinant Antibody (TAB-333CT) | WB, ELISA, FC, IP | Human IgG |
| TAB-332CT-S(P) | Anti-Human RON Recombinant Antibody scFv Fragment (TAB-332CT-S(P)) | WB, ELISA, FC | Human antibody |
| TAB-333CT-S(P) | Human Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-333CT-S(P)) | WB, ELISA, FC, IP | Human scFv |
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For Research Use Only. Not For Clinical Use.
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