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    Human Anti-MST1R Recombinant Antibody (clone Sh07F01 Hv3-48) (CAT#: HPAB-J0191-YC)

    Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d'Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON. It has shown that antibodies 07F01, 12B11, 17F06, 18H09 and 29B06 each inhibited MSP induced ERK phosphorylation in T47D cells, while only antibodies 07F01, 18H09 and 29B06 each blocked MSP binding to hRON SEMA+PSI in the neutralization assay. This suggests that antibodies 12B11 and 17F06 do not neutralize binding of MSP to the hRON SEMA+PSI domain, neutralize binding of MSP to RON in the context of the full RON extracellular domain, or function by a mechanism other than blocking MSP binding to RON.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/44_E6_1_selected.jpg
    Normal Tissue
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_9_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_6_6.jpg
    Figure 7 Skin
    Figure 7 Skin
    (Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_1.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_8_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
    Figure 9 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164078-MST1R

    Specifications

    • Immunogen
    • Recombinant human RON extracellular domain (hRON-ECD)
    • Host Species
    • Human
    • Derivation
    • Humanized (mouse/human)
    • Type
    • Humanized (mouse/human) IgG
    • Specificity
    • Human MST1R
    • Species Reactivity
    • Human
    • Clone
    • Sh07F01 Hv3-48
    • Applications
    • ELISA, Neut, FuncS

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE and HPLC analysis
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • Macrophage Stimulating 1 Receptor; PTK8 Protein Tyrosine Kinase 8; C-Met-Related Tyrosine Kinase; MSP Receptor; EC 2.7.10.1; P185-Ron; CDw136; PTK8

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone Sh07F01 Hv3-48"

    See other products for "MST1R"

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    Please select product type
    Mouse Antibody Products Human Antibody Products Blocking Antibody Products Neutralizing Antibody Products Rabbit Monoclonal Antibody Products IgG Antibody Products ScFv Antibody Products Fab Antibody Products ADCC Enhanced Antibody Products Antibody Magnetic Beads ScFv-Fc Chimera Products Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    TAB-331CT Anti-Human RON Recombinant Antibody (TAB-331CT) WB, ELISA, FC
    TAB-334CT Mouse Anti-MST1R Recombinant Antibody (TAB-334CT) WB, ELISA, FC, IP Mouse IgG2a, κ
    TAB-331CT-S(P) Anti-Human RON Recombinant Antibody scFv Fragment (TAB-331CT-S(P)) WB, ELISA, FC
    TAB-334CT-S(P) Mouse Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-334CT-S(P)) WB, ELISA, FC, IP Mouse scFv
    TAB-335CT-S(P) Mouse Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-335CT-S(P)) WB, ELISA, FC, IP Mouse scFv

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