Human Anti-MST1R Recombinant Antibody (clone Sh07F01 Hv3-48); scFv Fragment
CAT#: HPAB-J0191-YC-S(P)
Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d'Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON. It has shown that antibodies 07F01, 12B11, 17F06, 18H09 and 29B06 each inhibited MSP induced ERK phosphorylation in T47D cells, while only antibodies 07F01, 18H09 and 29B06 each blocked MSP binding to hRON SEMA+PSI in the neutralization assay. This suggests that antibodies 12B11 and 17F06 do not neutralize binding of MSP to the hRON SEMA+PSI domain, neutralize binding of MSP to RON in the context of the full RON extracellular domain, or function by a mechanism other than blocking MSP binding to RON.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/44_E6_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_6_6.jpg
Normal Tissue
Figure 7 Skin
Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_1.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164078-MST1R
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Specifications
- Immunogen
- Recombinant human RON extracellular domain (hRON-ECD)
- Host Species
- Human
- Derivation
- Humanized (mouse/human)
- Type
- Humanized (mouse/human) scFv
- Specificity
- Human MST1R
- Species Reactivity
- Human
- Clone
- Sh07F01 Hv3-48
- Applications
- ELISA, Neut, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-331CT | Anti-Human RON Recombinant Antibody (TAB-331CT) | WB, ELISA, FC | |
| TAB-334CT | Mouse Anti-MST1R Recombinant Antibody (TAB-334CT) | WB, ELISA, FC, IP | Mouse IgG2a, κ |
| TAB-335CT | Mouse Anti-MST1R Recombinant Antibody (TAB-335CT) | WB, ELISA, FC, IP | Mouse IgG2a, κ |
| TAB-331CT-F(E) | Anti-Human RON Recombinant Antibody Fab Fragment (TAB-331CT-F(E)) | WB, ELISA, FC | |
| TAB-334CT-F(E) | Mouse Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-334CT-F(E)) | WB, ELISA, FC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-332CT | Anti-Human RON Recombinant Antibody (TAB-332CT) | WB, ELISA, FC | Human antibody |
| TAB-333CT | Human Anti-MST1R Recombinant Antibody (TAB-333CT) | WB, ELISA, FC, IP | Human IgG |
| TAB-332CT-S(P) | Anti-Human RON Recombinant Antibody scFv Fragment (TAB-332CT-S(P)) | WB, ELISA, FC | Human antibody |
| TAB-332CT-F(E) | Anti-Human RON Recombinant Antibody Fab Fragment (TAB-332CT-F(E)) | WB, ELISA, FC | Human antibody |
| TAB-333CT-F(E) | Human Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-333CT-F(E)) | WB, ELISA, FC, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1756CQ | Recombinant Mouse Anti-MST1R Antibody (CBL312) | BL | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1757CQ | Recombinant Mouse Anti-MST1R Antibody (MM0478-10F24) | Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2309 | Hi-Affi™ Recombinant Rabbit Anti-MST1R Monoclonal Antibody (DS2309AB) | FC, ICC, IF, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0062-CN | Human Anti-MST1R Recombinant Antibody (clone MOR07923) | IP, ELISA, FC | Human IgG |
| HPAB-0063-CN | Human Anti-MST1R Recombinant Antibody (clone MOR07924) | IP, ELISA, FC | Human IgG |
| HPAB-0064-CN | Human Anti-MST1R Recombinant Antibody (clone MOR07925) | IP, ELISA, FC | Human IgG |
| HPAB-0706-FY | Mouse Anti-MST1R Recombinant Antibody (clone AB005) | ELISA | Mouse IgG |
| HPAB-0720-FY | Mouse Anti-MST1R Recombinant Antibody (clone AB034) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0062-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07923); scFv Fragment | IP, ELISA, FC | Human scFv |
| HPAB-0063-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07924); scFv Fragment | IP, ELISA, FC | Human scFv |
| HPAB-0064-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07925); scFv Fragment | IP, ELISA, FC | Human scFv |
| HPAB-0135-FY-S(P) | Human Anti-MST1R Recombinant Antibody (clone sh29B06-78); scFv Fragment | WB | Humanized scFv |
| HPAB-1589-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody Fab Fragment (HPAB-1589-FY-F(E)) | WB, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0135-FY-F(E) | Human Anti-MST1R Recombinant Antibody (clone sh29B06-78); Fab Fragment | WB | Humanized Fab |
| HPAB-687-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone 07F01); Fab Fragment | Inhib, ELISA, FC | Mouse Fab |
| HPAB-688-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone 29B06); Fab Fragment | Inhib, ELISA, FC | Mouse Fab |
| HPAB-689-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone 18H09); Fab Fragment | Inhib, ELISA, FC | Mouse Fab |
| HPAB-690-FY-F(E) | Human Anti-MST1R Recombinant Antibody (clone Sh07F01-2); Fab Fragment | Block | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-184 | Afuco™ Anti-MST1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-184) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY190 | AbPlus™ Anti-MST1R Magnetic Beads (MOR07923) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY152 | Human Anti-MST1R (clone M93-D02) scFv-Fc Chimera | WB, ELISA, FC, IP | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC486 | Recombinant Anti-MST1R Vesicular Antibody, EV Displayed (VS-0425-YC486) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4549 | Anti-MST1R Immunohistochemistry Kit | IHC |
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