Human Anti-MUC16 Recombinant Antibody Hexamer (VS-0924-YC140), CDC Enhanced (CAT#: VS-0924-YC140)

• Host Species
• Human

• Type
• Antibody hexamer

• Specificity
• Human MUC16

• Species Reactivity
• Human

• Molecule Class
• ~ 900 kDa

• Applications
• DB, WB, IP, ELISA, FC, CDC

• Conjugate
• None

• Related Disease
• Pancreatic tumor, ovarian cancer

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Purity
• >95% determined as SDS-PAGE and SEC-HPLC

• Aggregation
• <5%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

• Alternative Names
• MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; Medullary cystic kidney disease, autosomal dominant;

• Gene ID
• 4582

• UniProt ID
• P15941

• Long Name
• Mucin 16, Cell Surface Associated

• Sequence Similarities
• Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing between 12 and 60 partially conserved tandem repeats of 156 amino acids and a C-terminal transmembrane contain domain with a short cytoplasmic tail.

• Cellular Localization
• Cell membrane; Single-pass type I membrane protein
  Secreted, extracellular space

• Post Translation Modifications
• Heavily O-glycosylated; expresses both type 1 and type 2 core glycans. ( Q8WXI7-MUC16_HUMAN )
  Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans. ( Q8WXI7-MUC16_HUMAN )
  May be phosphorylated.
  Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
  ( Q8WXI7-MUC16_HUMAN )
  May contain numerous disulfide bridges.
  Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.

• Function
• Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. MUC16_HUMAN,Q8WXI7

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