Human Anti-MUC16 Recombinant Antibody Hexamer (VS-0924-YC140), CDC Enhanced
CAT#: VS-0924-YC140
The product is a human anti-MUC16 antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 antibody targets human MUC16 and contains hexamerization-enhancing mutations that promote hexamer formation. These modifications facilitate optimal C1q binding, thereby boosting CDC activity.
Gene Expression
Normal Tissue
Figure 1 Cervix
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65600/166228_B_7_3.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (A-431, HeLa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16
❮
❯
Specifications
- Host Species
- Human
- Type
- Antibody hexamer
- Specificity
- Human MUC16
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- DB, WB, IP, ELISA, FC, CDC
- Conjugate
- None
- Related Disease
- Pancreatic tumor, ovarian cancer
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; Medullary cystic kidney disease, autosomal dominant;
- Gene ID
- 4582
- UniProt ID
- P15941
- Long Name
- Mucin 16, Cell Surface Associated
- Sequence Similarities
- Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing between 12 and 60 partially conserved tandem repeats of 156 amino acids and a C-terminal transmembrane contain domain with a short cytoplasmic tail.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein
Secreted, extracellular space
- Post Translation Modifications
- Heavily O-glycosylated; expresses both type 1 and type 2 core glycans. ( Q8WXI7-MUC16_HUMAN )
Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans. ( Q8WXI7-MUC16_HUMAN )
May be phosphorylated.
Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
( Q8WXI7-MUC16_HUMAN )
May contain numerous disulfide bridges.
Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
- Function
- Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. MUC16_HUMAN,Q8WXI7
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Datasheet
MSDS
COA
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