Rabbit Anti-MUC2 Recombinant Antibody (clone R05-6J6) (CAT#: VS3-XY3438)
This antibody is a recombinant rabbit antibody targeting the MUC2 (Mucin 2, oligomeric mucus/gel-forming). MUC2 coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. This antibody specifically targets human and rat MUC2. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
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Normal Tissue
Figure 1 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16275/35623_B_8_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16275/35623_B_8_5.jpg
Figure 2 Small intestine
(Endocrine cells Staining: High Intensity: Strong Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16275/35623_A_6_2.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16275/35623_A_6_2.jpg
Figure 3 High expression in colon.
(Endocrine cells Staining: High Intensity: Strong Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16275/35623_A_9_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16275/35623_A_9_3.jpg
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat MUC2
- Species Reactivity
- Human, Rat
- Clone
- R05-6J6
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Pseudomyxoma Peritonei; Gastric Cancer
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- MLP; SMUC; MUC-2
- Gene ID
- 4583
- UniProt ID
- Q02817
- Long Name
- Mucin 2, oligomeric mucus/gel-forming
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn163, Asn423, Asn670, Asn770, Asn894, Asn1139, Asn1154, Asn1215, Asn1230, Asn1246, Asn1787, Asn1820, Asn4339, Asn4351, Asn4362, Asn4373, Asn4422, Asn4438, Asn4502, Asn4616, Asn4627, Asn4752, Asn4787, Asn4881, Asn4888, Asn4955, Asn4970, Asn5019, Asn5038, and Asn5069 (NX_Q02817 [NX_Q02817-1])
Modification sites at PhosphoSitePlus (Q02817)
Glycosylation from GlyConnect MUC2_HUMAN (1519, 373)
Glycosylation from GlyGen (Q02817) 46 sites, 51 O-linked glycans (1 site)
- Protein Refseq
- NP_002448.5
- Function
- Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine.
MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange.
Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1800z | Mouse Anti-MUC2 Recombinant Antibody (clone 39D2) | WB, ELISA, FC, IF, IHC, IP | Mouse IgG1, κ |
| MOB-1261CT | Recombinant Mouse anti-Human MUC2 Monoclonal antibody (005/263) | ELISA | |
| MRO-1042-CN | Recombinant Rabbit Anti-MUC2 Monoclonal Antibody (JA10-92) | WB, IF, IHC, FC | Rabbit IgG |
| MOB-0112F | Mouse Anti-MUC2 Recombinant Antibody (MOB-0112F) | IHC-P, IF | Mouse IgG |
| VS3-WK222 | Rabbit Anti-MUC2 Recombinant Antibody (clone JA10-92) | WB, ICC, IF, IHC, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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