Rabbit Anti-MUC2 Recombinant Antibody (clone R05-6J6)
CAT#: VS3-XY3438
This antibody is a recombinant rabbit antibody targeting the MUC2 (Mucin 2, oligomeric mucus/gel-forming). MUC2 coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. This antibody specifically targets human and rat MUC2. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16275/35623_B_8_5.jpg
Normal Tissue
Figure 2 Small intestine
Endocrine cells Staining: High Intensity: Strong Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16275/35623_A_6_2.jpg
Normal Tissue
Figure 3 High expression in colon.
Endocrine cells Staining: High Intensity: Strong Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16275/35623_A_9_3.jpg
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat MUC2
- Species Reactivity
- Human, Rat
- Clone
- R05-6J6
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Pseudomyxoma Peritonei; Gastric Cancer
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- MLP; SMUC; MUC-2
- Gene ID
- 4583
- UniProt ID
- Q02817
- Long Name
- Mucin 2, oligomeric mucus/gel-forming
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn163, Asn423, Asn670, Asn770, Asn894, Asn1139, Asn1154, Asn1215, Asn1230, Asn1246, Asn1787, Asn1820, Asn4339, Asn4351, Asn4362, Asn4373, Asn4422, Asn4438, Asn4502, Asn4616, Asn4627, Asn4752, Asn4787, Asn4881, Asn4888, Asn4955, Asn4970, Asn5019, Asn5038, and Asn5069 (NX_Q02817 [NX_Q02817-1])
Modification sites at PhosphoSitePlus (Q02817)
Glycosylation from GlyConnect MUC2_HUMAN (1519, 373)
Glycosylation from GlyGen (Q02817) 46 sites, 51 O-linked glycans (1 site)
- Protein Refseq
- NP_002448.5
- Function
- Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine.
MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange.
Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MUC2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1800z | Mouse Anti-MUC2 Recombinant Antibody (clone 39D2) | WB, ELISA, FC, IF, IHC, IP | Mouse IgG1, κ |
| MOB-1261CT | Recombinant Mouse anti-Human MUC2 Monoclonal antibody (005/263) | ELISA | |
| MRO-1042-CN | Recombinant Rabbit Anti-MUC2 Monoclonal Antibody (JA10-92) | WB, IF, IHC, FC | Rabbit IgG |
| MOB-0112F | Mouse Anti-MUC2 Recombinant Antibody (MOB-0112F) | IHC-P, IF | Mouse IgG |
| MOB-0113F | Mouse Anti-MUC2 Recombinant Antibody (MOB-0113F) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2322 | Hi-Affi™ Recombinant Rabbit Anti-MUC2 Monoclonal Antibody (DS2322AB) | WB, IHC, ICC, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1395 | Anti-MUC2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4581 | Anti-Mouse MUC2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4580 | Anti-Human MUC2 Immunohistochemistry Kit | IHC |
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