Rabbit Anti-MUC4 Recombinant Antibody (clone R05-7I9) (CAT#: VS3-FY1781)

This recombinant monoclonal antibody exhibits a robust affinity for human MUC4. The presence of the Mucin 4 antibody was identified through immunohistochemistry examination of paraffin-embedded appendix samples. This R05-7I9 antibody is validated for immunohistochemistry analysis of paraffin-embedded Appendix.

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IHC

Figure 1 Anti-MUC4 Antibody (VS3-FY1781) in IHC.

Figure 1 Anti-MUC4 Antibody (VS3-FY1781) in IHC.

Immunohistochemistry staining of paraffin-embedded Appendix using the anti-Mucin 4 antibody. High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.


Specifications

  • Immunogen
  • Recombinant human MUC4 protein
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human MUC4
  • Species Reactivity
  • Human
  • Clone
  • R05-7I9
  • Applications
  • Western Blot
  • MW
  • The calculated weight of the target protein is approximately 542 kDa, while the observed molecular weight stands at 120 kDa.
  • Related Disease
  • Biliary Tract Cancer and Mucoepidermoid Carcinoma

Product Property

  • Purification
  • Affinity Purified
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Western Blot: 1/500-1/1000

Target

  • Alternative Names
  • Mucin 4, Cell Surface Associated; Pancreatic Adenocarcinoma Mucin; Mucin 4, Tracheobronchial; Ascites Sialoglycoprotein; Tracheobronchial Mucin; Testis Mucin
  • Cellular Localization
  • Cell membrane, Membrane, Secreted
  • Post Translation Modifications
  • Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain.
  • Function
  • These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation.
    Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor.

Recommended Products

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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