Anti-MYC (clone W24V174) Recombinant Antibody Coupled Liposome (VS-1024-FY175) (CAT#: VS-1024-FY175)

• Potential Clinical Applications
• Melanoma

• Clone
• W24V174

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant mouse monoclonal antibody that was specifically designed to bind to the c-Myc protein. c-Myc is a crucial transcription factor that plays a significant role in cell growth, proliferation, and differentiation. Due to its involvement in various cellular processes, dysregulation of c-Myc is often associated with several types of cancers.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• MYC

• Introduction
• This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

• Alternative Names
• MYC Proto-Oncogene, BHLH Transcription Factor; V-Myc Avian Myelocytomatosis Viral Oncogene Homolog; Class E Basic Helix-Loop-Helix Protein 39; Transcription Factor P64; Proto-Oncogene C-Myc; BHLHe39; Myc-Related Translation/Localization Regulatory Factor

• Full Name
• MYC Proto-Oncogene, BHLH Transcription Factor

• Gene ID
• 4609

• UniProt ID
• P01106

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Phosphorylated by PRKDC (PubMed:1597196).
  Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity).
  Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence (PubMed:19966300, PubMed:20713526).
  Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58 (PubMed:22307329).
  Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome (PubMed:15103331, PubMed:17558397, PubMed:8386367).
  Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (PubMed:25803737, PubMed:25438055).
  Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome (PubMed:15103331, PubMed:17558397, PubMed:25775507).
  In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation (PubMed:17873522, PubMed:17558397).
  In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus (PubMed:17558397, PubMed:25775507).
  Also polyubiquitinated by the DCX(TRPC4AP) complex (PubMed:20551172, PubMed:29779948).
  Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).

• Protein Refseq
• NP_002458.2

• Function
• Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029).
  Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029).
  Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029).
  Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity).
  Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).
  Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808).

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