Anti-NAMPT (clone W24V112) Recombinant Antibody Coupled Liposome (VS-1024-FY114)
CAT#: VS-1024-FY114
Anti-NAMPT antibody-conjugated liposomes show potential in the treatment of gliomas. NAMPT is a key enzyme involved in the synthesis of NAD (nicotinamide adenine dinucleotide), and tumor cells tend to utilize this pathway to sustain survival and proliferation. Additionally, antibody-drug conjugates (ADCs) targeting NAMPT have emerged as an effective delivery form in the treatment of both solid tumors and hematological cancers, facilitating targeted therapy.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nuclear speckles & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57722/1043_H9_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows moderate cytoplasmic positivity in germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47776/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human spleen
Immunohistochemical staining of human spleen shows moderate to strong cytoplasmic positivity in cells of white and red pulp.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34349/157328_B_7_4_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47776/114368_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47776/114368_A_5_6.jpg
Normal Tissue
Figure 6 Appendix
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Lymphoid tissue Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47776/114368_A_3_2.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105835-NAMPT
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V112
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that specifically targets human NAMPT, a protein that plays a crucial role in the regulation of nicotinamide adenine dinucleotide (NAD+) metabolism. By binding selectively to NAMPT, this antibody can be utilized in various research applications to study its implications in metabolic disorders and cancer biology. Furthermore, the unique specificity of this antibody enhances its potential for therapeutic development and diagnostic purposes in conditions associated with altered NAMPT activity.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- NAMPT
- Introduction
- This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10.
- Alternative Names
- Nicotinamide Phosphoribosyltransferase; Visfatin; Pre-B-Cell Colony-Enhancing Factor 1; Pre-B Cell-Enhancing Factor; EC 2.4.2.12; NAmPRTase; PBEF1
- Full Name
- Nicotinamide Phosphoribosyltransferase
- Gene ID
- 10135
- UniProt ID
- P43490
- Sequence Similarities
- Belongs to the NAPRTase family.
- Cellular Localization
- Nucleus; Cytoplasm; Secreted
- Post Translation Modifications
- Ubiquitination at Lys99, Lys189, Lys342, and Lys371 ( NX_P43490 [NX_P43490-1] )
Modification sites at PhosphoSitePlus ( P43490 )
Glycosylation from GlyGen (P43490) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047275655.1; XP_047275656.1; XP_054212959.1; XP_054212960.1; NP_005737.1
- Function
- Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD.
It is the rate limiting component in the mammalian NAD biosynthesis pathway.
The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma.
Plays a role in the modulation of circadian clock function.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "NAMPT"
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|---|---|---|---|
| MOR-2362 | Hi-Affi™ Recombinant Rabbit Anti-NAMPT Monoclonal Antibody (DS2362AB) | WB, IHC-P, ICC | IgG |
| MOR-4653 | Hi-Affi™ Recombinant Rabbit Anti-NAMPT Monoclonal Antibody (TH166DS) | WB, IF, ICC, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0358C | Mouse Anti-NAMPT Recombinant Antibody (ZG-0358C) | WB, ELISA | Mouse IgG |
| ZG-0359C | Mouse Anti-NAMPT Recombinant Antibody (ZG-0359C) | WB, ELISA | Mouse IgG |
| VS3-FY2817 | Rabbit Anti-NAMPT Recombinant Antibody (VS3-FY2817) | WB, IHC, ICC, IP | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC822 | AbPlus™ Anti-NAMPT Magnetic Beads (VS-0724-YC822) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1447 | Anti-NAMPT Immunohistochemistry Kit | IHC | |
| VS-0525-XY4682 | Anti-Mouse NAMPT Immunohistochemistry Kit | IHC | |
| VS-0525-XY4681 | Anti-Human NAMPT Immunohistochemistry Kit | IHC |
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