Anti-NES (clone W24V115) Recombinant Antibody Coupled Liposome (VS-1024-FY117)
CAT#: VS-1024-FY117
Anti-NES antibody-conjugated liposomes represent a promising advancement in glioma treatment, offering a novel approach to targeted drug delivery. By utilizing specific antibodies that recognize and bind to tumor cells, this system enhances the precision of drug distribution, ensuring that therapeutic agents directly reach the malignant cells while sparing healthy tissue. This targeted delivery not only boosts the overall effectiveness of the treatment but also minimizes adverse side effects commonly associated with traditional chemotherapy, paving the way for improved outcomes for patients with gliomas.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6286/1401_E3_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26111/1783_C4_5_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5889/613_B1_1_selected.jpg
Normal Tissue
Figure 4 Spleen
High expression in spleen
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7007/20723_B_8_4_val_selected.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26111/58753_B_7_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26111/58753_A_7_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26111/58753_A_8_5.jpg
Normal Tissue
Figure 8 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26111/58753_B_4_6.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (AF22, HUVEC TERT2, LHCN-M2, RH-30, SuSa, WM-115)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000132688-NES
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V115
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody designed to specifically target human nestin (NES). Nestin is an intermediate filament protein that plays a crucial role in the development of the nervous system and is often used as a marker for neural stem cells. By binding selectively to human NES, this antibody can be an invaluable tool for research and therapeutic applications related to neurodevelopmental studies and regenerative medicine.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- NES
- Introduction
- This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells.
- Alternative Names
- Nestin
- Full Name
- Nestin
- Gene ID
- 10763
- UniProt ID
- P48681
- Sequence Similarities
- Belongs to the intermediate filament family.
- Post Translation Modifications
- Constitutively phosphorylated.
This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).
( P48681-NEST_HUMAN )
Modification sites at PhosphoSitePlus ( P48681 )
Modification sites at neXtProt ( NX_P48681 )
Glycosylation from GlyGen (P48681) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_006608.1
- Function
- Required for brain and eye development.
Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
- CAT
- Product Name
See other products for "NES"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1670z | Mouse Anti-NES Recombinant Antibody (clone 28C6) | WB, FC, ICC, IHC, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1043MZ | Recombinant Mouse Anti-Human NES Antibody (clone 3D2.4B22) | FC, IP WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0721MZ | Chicken Anti-Nes Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2422 | Hi-Affi™ Recombinant Rabbit Anti-NES Monoclonal Antibody (DS2422AB) | IHC-P, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1075-CN | Recombinant Rabbit Anti-NES Monoclonal Antibody (CBACN-397) | IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2064-CN | Rabbit Anti-NES Polyclonal Antibody (MRO-2064-CN) | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2065-CN | Rabbit Anti-NES Polyclonal Antibody (MRO-2065-CN) | IF, IHC, FC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0108-FY | Rabbit Anti-NES Recombinant Antibody (clone AFY0079) | ICC, IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC623 | AbPlus™ Anti-NES Magnetic Beads (VS-0724-YC623) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC624 | AbPlus™ Anti-NES Magnetic Beads (VS-0724-YC624) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC75 | Mouse Anti-NES Recombinant Antibody (VS-0924-YC75) - Cancer Stem Cell Marker | IHC, WB, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC78 | Rabbit Anti-NES Antibody (VS-0924-YC78) - Cancer Stem Cell Marker | IHC, WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4792 | Anti-NES Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4793 | Anti-Mouse NES Immunohistochemistry Kit | IHC |
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