Anti-NFKB2 Antibody Prodrug, Protease Activated (SAIC-26C-15)
CAT#: VS-1025-YC169
The Anti-NFKB2 Antibody Prodrug, Protease Activated (SAIC-26C-15) is an antibody prodrug comprised of a recombinant mouse antibody targeting human NFKB2, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to NFKB2 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to NFKB2 effectively. NFKB2 is a component of the NF-κB transcription factor family whose abnormal activation is a crucial mechanism of survival and drug resistance in many cancers, particularly multiple myeloma and lymphoma. Translocations or mutations that activate NFKB2 drive continuous pro-survival gene expression.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8422/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows strong positivity in enocrine and exocrine cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22098/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22098/if_selected.jpg
Normal Tissue
Figure 4 Appendix
High expression in appendix
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8422/23094_A_1_2_val_selected.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8422/23094_A_7_5.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8422/23094_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077150-NFKB2
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human NFKB2
- Target
- NFKB2
- Species Reactivity
- Human
- Isotype
- IgG1
- Clone
- SAIC-26C-15
- Epitope
- IEVDLVTHSDPPR
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
- Alternative Names
- Nuclear Factor Kappa B Subunit 2; Lymphocyte Translocation Chromosome 10 Protein; DNA-Binding Factor KBF2; Oncogene Lyt-10; H2TF1; LYT10
- Gene ID
- 4791
- UniProt ID
- Q00653
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Related Signaling Pathways
BCR Signaling Pathway
cAMP Signaling Pathway
NLR Signaling Pathway
TCR Signaling Pathway
TLR Signaling Pathway
TNF Signaling Pathway
Related Diseases
Maturity Onset Diabetes of the Young
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone SAIC-26C-15"
- CAT
- Product Name
See other products for "NFKB2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4053z | Mouse Anti-NFKB2 Recombinant Antibody (clone 29B2) | WB, IP, IF, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1185CT | Recombinant Mouse anti-Human NFKB2 Monoclonal antibody (0.U.284) | GSA, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2434 | Hi-Affi™ Recombinant Rabbit Anti-NFKB2 Monoclonal Antibody (DS2434AB) | IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1089-CN | Recombinant Rabbit Anti-NFKB2 Monoclonal Antibody (JM82-03) | WB, IF, IHC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1228CQ | Mouse Anti-NFKB2 Recombinant Antibody (clone SAIC-26C-15) | Immuno-MRM, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1034 | Recombinant Rabbit Anti-NFKB2 Antibody (clone R01-8B2) | WB, ICC, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1495 | Anti-NFKB2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4819 | Anti-Mouse NFKB2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4818 | Anti-Human NFKB2 Immunohistochemistry Kit | IHC |
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