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    Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H11) (CAT#: AFC-TAB-H11)

    This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human NOTCH1

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    • Purity:

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    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line HaCaT
    Figure 1 IF staining of human cell line HaCaT
    (Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/67168/1315_F7_4_selected.jpg
    Normal Tissue
    Figure 2 IHC staining of human pancreas
    Figure 2 IHC staining of human pancreas
    (Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/22466/61564_A_3_3_selected.jpg
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_B_8_5.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Fibroblasts Staining: High Intensity: Strong Mucosal lymphoid cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_3.jpg
    Figure 5 Liver
    Figure 5 Liver
    (Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_4.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_6_6.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
    Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148400-NOTCH1

    Specifications

    • Host Species
    • Human
    • Derivation
    • Humanized (from mouse)
    • Type
    • ADCC enhanced antibody
    • Specificity
    • NOTCH1 (notch 1, translocation-associated notch-1, TAN-1, TAN1) [Homo sapiens]
    • Species Reactivity
    • Human
    • Applications
    • FC, IP, ELISA, Neut, FuncS, IF
    • Conjugate
    • Unconjugated
    • Generic Name
    • Brontictuzumab
    • Related Disease
    • Lymphoma

    Product Property

    • Purity
    • >95% by SDS-PAGE
    • Storage
    • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • NOTCH1; notch 1; Notch (Drosophila) homolog 1 (translocation associated), Notch homolog 1, translocation associated (Drosophila), TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated

    Related Resources

    • Biosimilar Overview
    • Related Diseases
    Please refer to Brontictuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Brontictuzumab.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "brontictuzumab"

    Anti-Human NOTCH1 Recombinant Antibody (Brontictuzumab)
    Recombinant Humanized (from mouse) antibody to Human NOTCH1
    DrugMonitor™ Anti-Brontictuzumab Antibody (VS-1224-YC226)
    Brontictuzumab has been used in trials for treating Adenoid Cystic Carcinoma, relapsed or refractory solid tumors, and relapsed or refractory lymphoid malignancies. The DrugMonitor™ Anti-Brontictuzumab Antibody (VS-1224-YC226) is an anti-drug antibody (ADA) against Brontictuzumab. This drug-based antibody is raised in mice immunized with the Brontictuzumab. The anti-Brontictuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Brontictuzumab in samples.

    See other products for "NOTCH1"

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    MOB-1747z Mouse Anti-NOTCH1 Recombinant Antibody (clone 21H9) WB, ICC, IF, IHC Mouse IgG2b
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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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