Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133) (CAT#: HPAB-AP750-YC)
Provided are fully human monoclonal antibodies that specifically bind to a cell surface receptor, wherein the receptor protein is a Notch1 receptor protein. The antibody can be used for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1 or Notch3 including aberrant activation of each of these receptors.
Specific Inquiry
ELISA
Figure 1 Binding affinity determination (EC50) in ELISA using different concentrations of purified IgG protein.
Three mAbs binding to Notch 1 ligand binding domain antigen (Alal9-Gln526).
Block
Figure 2 Notch 1 mAb blocking Notchl /Fc and Notchl ligand interaction.
IgG is the isotype non-blocker control and four Notch 1 ligand blocking Mabs are shown as indicated.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human NOTCH1
- Species Reactivity
- Human
- Clone
- N1wc133
- Applications
- ELISA, Block
- Related Disease
- Pathological hyperproliferative oncogenic disorders
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-Linked Immunosorbent Assay and Blocking.
Target
- Alternative Names
- Notch 1; Translocation-Associated Notch Protein TAN-1; TAN1; HN1; Notch (Drosophila) Homolog 1 (Translocation-Associated); Notch Homolog 1, Translocation-Associated (Drosophila); Notch Homolog 1, Translocation-Associated
- Gene ID
- 4851
- UniProt ID
- P46531
Related Resources
Breast Cancer
Endocrine Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone N1wc133"
See other products for "NOTCH1"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H11 | Anti-Human NOTCH1 Recombinant Antibody (Brontictuzumab) | Inhib | IgG2 - lambda |
| TAB-541MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-541MZ) | Neut, WB | Humanized antibody |
| TAB-542MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-542MZ) | Neut, WB | Humanized antibody |
| TAB-544MZ | Anti-Human NOTCH1 Recombinant Antibody (A12.2) | ELISA, FuncS, Inhib | Humanized antibody |
| TAB-541MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-541MZ-S(P)) | WB, Competition ELISA | Humanized scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-539MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-539MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
| TAB-540MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-540MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
| TAB-543MZ | Anti-Human NOTCH1 Recombinant Antibody (mAb N248A) | ELISA, WB, Luciferase reporter assay | |
| TAB-539MZ-F(E) | Rat Anti-NOTCH1 Recombinant Antibody; Fab Fragment (TAB-539MZ-F(E)) | WB, Competition ELISA | Rat Fab |
| TAB-540MZ-F(E) | Rat Anti-NOTCH1 Recombinant Antibody; Fab Fragment (TAB-540MZ-F(E)) | WB, Competition ELISA | Rat Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-545MZ-F(E) | Anti-Human NOTCH1 Recombinant Antibody Fab Fragment (23814) | ELISA | Human antibody |
| TAB-546MZ-F(E) | Anti-Human NOTCH1 Recombinant Antibody Fab Fragment (23418.8) | ELISA | Human antibody |
| TAB-547MZ-F(E) | Human Anti-NOTCH1 Recombinant Antibody; Fab Fragment (TAB-547MZ-F(E)) | ELISA | Human Fab |
| TAB-548MZ-F(E) | Human Anti-NOTCH1 Recombinant Antibody; Fab Fragment (TAB-548MZ-F(E)) | ELISA | Human Fab |
| PABX-152-F (E) | Recombinant Human Anti-NRR1 Antibody Fab Fragment | ELISA, Neut, FuncS | Fab |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1786CQ | Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519) | FC, BL | IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2473 | Hi-Affi™ Recombinant Rabbit Anti-NOTCH1 Monoclonal Antibody (DS2473AB) | WB, IHC | IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-060CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6) | FC, IF, ELISA, Inhib, FuncS | Mouse IgG1 |
| NS-061CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10) | FC, IF, ELISA | Mouse IgG1 |
| NS-062CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11) | FC, IF, ELISA, Inhib | Mouse IgG2b |
| NS-063CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11) | FC, IF, ELISA | Mouse IgG1 |
| NS-063CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); scFv Fragment | FC, IF, ELISA | Mouse scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-060CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| NS-061CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| NS-062CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| HPAB-AP750-YC-S(P) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-AP751-YC-S(P) | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155); scFv Fragment | ELISA, FC | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H11 | Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody (Brontictuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0681-WJ | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51) | ELISA, WB | Humanized IgG |
| HPAB-AP751-YC | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155) | Block | Human IgG1 |
| HPAB-AP752-YC | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc49) | ELISA | Human IgG1 |
| HPAB-AP753-YC | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc104) | ELISA, FC | Human IgG1 |
| HPAB-AP754-YC | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc629) | ELISA | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP750-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-AP751-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-AP752-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc49); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-AP753-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc104); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-AP754-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc629); Fab Fragment | ELISA, FC | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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