Rabbit Anti-NOTCH3 Antibody (VS-0924-YC81) - Cancer Stem Cell Marker
CAT#: VS-0924-YC81
This product is an anti-NOTCH3 antibody (VS-0924-YC81) that targets the human NOTCH3 protein, a marker of cancer stem cells (CSCs). It is suitable for detecting NOTCH3 in CSC tissues or cells by immunofluorescence, with a recommended concentration of 0.5-2 µg/mL.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, cytosol & actin filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44392/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44392/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows strong nuclear and moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_A_8_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_A_8_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_A_8_5.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AF22, MCF7, RT4, U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000074181-NOTCH3
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human NOTCH3
- Species Reactivity
- Human
- Applications
- IF
Product Property
- Clonality
- Polyclonal
- Purification
- Affinity purified using the PrEST antigen as affinity ligand
- Concentration
- 0.1 mg/mL
- Buffer
- PBS, pH 7.2, with 40% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunofluorescence (IF): 0.5-2 µg/mL
Target
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Related Diseases
Breast Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "NOTCH3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1929z | Mouse Anti-NOTCH3 Recombinant Antibody (clone 22H2) | WB, ELISA | Mouse IgG2a |
| HPAB-1010WJ | Human Anti-NOTCH3 Recombinant Antibody (clone N3WCR3P1B12) | ELISA, WB, FC | Human IgG |
| HPAB-1011WJ | Human Anti-NOTCH3 Recombinant Antibody (clone hN3S2_160) | ELISA, WB, FC | Human IgG |
| HPAB-1012WJ | Human Anti-NOTCH3 Recombinant Antibody (clone N3LHCS_18) | ELISA, WB, FC | Human IgG |
| HPAB-1013WJ | Human Anti-NOTCH3 Recombinant Antibody (clone N1wc561) | ELISA, WB, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-557MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-557MZ) | Inhib, Neut | Chimeric (mouse/human) IgG1 |
| TAB-557MZ-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-557MZ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-557MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-557MZ-F(E)) | ELISA, WB | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-558MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-558MZ) | Inhib, Neut | Humanized IgG1 |
| TAB-558MZ-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-558MZ-S(P)) | ELISA, WB | Humanized scFv |
| TAB-558MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-558MZ-F(E)) | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-554MZ-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-554MZ-S(P)) | ELISA | Human scFv |
| TAB-554MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-554MZ-F(E)) | ELISA | Human Fab |
| TAB-555MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-555MZ-F(E)) | ELISA | Human Fab |
| TAB-560MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-560MZ-F(E)) | FC | Human Fab |
| TAB-561MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-561MZ-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0282-YC-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody (clone 122M23); scFv Fragment | ELISA, IHC, WB | Mouse scFv |
| HPAB-0283-YC-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody; scFv Fragment (HPAB-0283-YC-S(P)) | ELISA, IHC, WB | Mouse scFv |
| HPAB-0284-YC-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody; scFv Fragment (HPAB-0284-YC-S(P)) | ELISA, IHC, WB | Mouse scFv |
| HPAB-M0577-YC-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (HPAB-M0577-YC-S(P)) | FC, WB, Inhib | Human scFv |
| HPAB-0754-WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone N37); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0282-YC-F(E) | Mouse Anti-NOTCH3 Recombinant Antibody (clone 122M23); Fab Fragment | ELISA, IHC, WB | Mouse Fab |
| HPAB-0283-YC-F(E) | Mouse Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-0283-YC-F(E)) | ELISA, IHC, WB | Mouse Fab |
| HPAB-0284-YC-F(E) | Mouse Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-0284-YC-F(E)) | ELISA, IHC, WB | Mouse Fab |
| HPAB-M0577-YC-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-M0577-YC-F(E)) | FC, WB, Inhib | Human Fab |
| HPAB-M0578-YC-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-M0578-YC-F(E)) | FC, WB, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY161 | Human Anti-NOTCH3 scFv-Fc Chimera (VS-0425-FY161) | ELISA, FC, WB | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC122 | Recombinant Anti-NOTCH3 Vesicular Antibody, EV Displayed (VS-0425-YC122) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4910 | Anti-NOTCH3 Immunohistochemistry Kit | IHC |
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