Anti-NTRK1 Antibody Prodrug, Protease Activated (VS-1025-YC56)

Name: Anti-NTRK1 Antibody Prodrug, Protease Activated (VS-1025-YC56)
SKU: VS-1025-YC56
Rating: 5 (1 reviews)

CAT#: VS-1025-YC56

The Anti-NTRK1 Antibody Prodrug, Protease Activated (VS-1025-YC56) is an antibody prodrug comprised of a recombinant human antibody targeting human NTRK1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to NTRK1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to NTRK1 effectively. NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1) is a receptor tyrosine kinase that is not an oncogene itself, but it becomes a potent driver of cancer when involved in gene fusions, typically resulting from chromosomal rearrangements. These fusions, found across many solid tumor types, create a constantly active TRK fusion protein that drives relentless proliferation and survival of the cancer cell. The presence of these NTRK1 fusions makes the tumors highly sensitive to targeted inhibitors, which are now a major therapeutic option for patients with TRK-fusion positive malignancies.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line SH-SY5Y

Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76570/1680_E8_5_selected.jpg

Subcellular Location Figure 2 IHC staining of human cerebral cortex

Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/ihc_selected.jpg

Subcellular Location Figure 3 IHC staining of human cerebellum

Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4606/ihc_selected.jpg

Normal Tissue Figure 4 Cerebral cortex

Glial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Neuronal cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_B_9_5.jpg

Normal Tissue Figure 5 Colon

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_A_9_3.jpg

Normal Tissue Figure 6 Testis

Elongated or late spermatids
Staining:

Medium

Intensity: Moderate
Quantity:>75%

Pachytene spermatocytes
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%

Round or early spermatids
Staining:

Medium

Intensity: Moderate
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_A_6_6.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enriched (HMC-1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198400-NTRK1

❮

❯

Specifications

Host Animal
Human

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human NTRK1

Target
NTRK1

Species Reactivity
Human

Isotype
IgG1, kappa

Affinity Constant
K_D = 1.6 nM

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Alternative Names
MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA

Gene ID
4914

UniProt ID
P04629

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

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Datasheet

Datasheet - VS-1025-YC56.pdf

MSDS

MSDS - VS-1025-YC56.pdf

COA

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