AbPlus™ Anti-NTRK1 Magnetic Beads (CBACN-560)

Name: AbPlus™ Anti-NTRK1 Magnetic Beads (CBACN-560)
SKU: VS-0424-XY207
Rating: 5 (1 reviews)

CAT#: VS-0424-XY207

The AbPlus Anti-NTRK1 Magnetic Beads (CBACN-560) is an innovative affinity resin which is bound with anti-NTRK1 specific antibody (CBACN-560). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of NTRK1 protein under native and denaturing conditions.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line SH-SY5Y

Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76570/1680_E8_5_selected.jpg

Subcellular Location Figure 2 IHC staining of human cerebral cortex

Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/ihc_selected.jpg

Subcellular Location Figure 3 IHC staining of human cerebellum

Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4606/ihc_selected.jpg

Normal Tissue Figure 4 Cerebral cortex

Glial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Neuronal cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_B_9_5.jpg

Normal Tissue Figure 5 Colon

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_A_9_3.jpg

Normal Tissue Figure 6 Testis

Elongated or late spermatids
Staining:

Medium

Intensity: Moderate
Quantity:>75%

Pachytene spermatocytes
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%

Round or early spermatids
Staining:

Medium

Intensity: Moderate
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_A_6_6.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enriched (HMC-1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198400-NTRK1

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Specifications

Applications
Immunoprecipitation, Protein Purification

Matrix
Magrose bead (> 50 μmol/mL gel)

Bead Ligand
Anti-NTRK1 specific antibody (CBACN-560)

Target
NTRK1

Immunogen
Human NTRK1 (aa 750-850)

Target Species
Human, Mouse, Rat

Antibody Clone
CBACN-560

Bead Capacity
20-30 mg/mL binding antibody

Bead size
10-37 μm

Stability
pH 2-14

Format
20% Suspension

Buffer
PBS, pH 7.4, with 1% BSA

Preservative
0.03% Proclin 300

Storage
Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

Applications

Application Notes
The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

Target

Introduction
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Alternative Names
Neurotrophic Receptor Tyrosine Kinase 1; Neurotrophic Tyrosine Kinase, Receptor, Type 1; High Affinity Nerve Growth Factor Receptor; TRK1-Transforming Tyrosine Kinase Protein; Tropomyosin-Related Kinase A; Tyrosine Kinase Receptor A; EC 2.7.10.1; P140-TrkA; Gp140trk; Trk-A

Gene ID
4914

UniProt ID
P04629

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

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Datasheet

Datasheet - VS-0424-XY207.pdf

MSDS

MSDS - VS-0424-XY207.pdf

COA

Certificate of Analysis Lookup

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