Rabbit Anti-NTRK2 Recombinant Antibody (VS3-CJ368)
CAT#: VS3-CJ368
This product is a rabbit antibody that recognizes NTRK2.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7637/202_C1_1_selected.jpg
Normal Tissue
Figure 2 High expression in cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_B_7_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, HaCaT, RPTEC TERT1, SH-SY5Y, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148053-NTRK2
❮
❯
Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat NTRK2
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunohistochemistry.
Target
- Alternative Names
- DEE58; EIEE58; GP145-TrkB; OBHD; TRKB; trk-B
- Gene ID
- 4915
- UniProt ID
- Q16620
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
- Cellular Localization
- Cell membrane, Cell projection, Cytoplasm, Endosome, Membrane, Synapse
- Post Translation Modifications
- Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated.
Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).
- Protein Refseq
- NP_001007098.1; NP_001018074.1; NP_001018075.1
- Function
- Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity).
Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731).
Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731).
Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS3-CJ368. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "NTRK2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-171CQ | Anti-Human NTRK2 Recombinant Antibody (18H6) | ELISA, FC | |
| TAB-173CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (6B72C5) | ELISA, WB, IP | |
| TAB-174CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (5G5D2B5) | ELISA, WB, IP | |
| TAB-175CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (17D11) | ELISA, FC, WB | |
| TAB-176CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (29D7) | ELISA, FC, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-177CQ | Anti-Human NTRK2 Recombinant Antibody (C2) | Agonist, FuncS | Humanized antibody |
| TAB-178CQ | Anti-Human NTRK2 Recombinant Antibody (A2) | ELISA, FC | Humanized antibody |
| TAB-177CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C2) | ELISA, FC | Humanized antibody |
| TAB-178CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (A2) | ELISA, FC | Humanized antibody |
| TAB-179CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (RN1026A) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-180CQ | Anti-Human NTRK2 Recombinant Antibody (C20) | FuncS | Human antibody |
| TAB-180CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C20) | ELISA, FC, WB | Human antibody |
| TAB-180CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C20) | ELISA, FC, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0842MZ | Recombinant Mouse Anti-Human NTRK2 Antibody (clone 3D12) | WB | Mouse antibody |
| HPAB-AP761-YC | Human Anti-NTRK2 Recombinant Antibody (clone 4A6) | FuncS | Humanized IgG |
| HPAB-AP762-YC | Human Anti-NTRK2 Recombinant Antibody (clone 4B12) | FuncS | Humanized IgG |
| HPAB-AP763-YC | Human Anti-NTRK2 Recombinant Antibody (clone C1) | FuncS | Humanized IgG |
| HPAB-AP764-YC | Human Anti-NTRK2 Recombinant Antibody (clone 4B12-17) | Agonist | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2509 | Hi-Affi™ Recombinant Rabbit Anti-NTRK2 Monoclonal Antibody (DS2509AB) | WB, IHC, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-095CN | Human Anti-NTRK2 Recombinant Antibody (NS-095CN) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0663-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0663-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0664-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0664-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0665-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0665-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-AP761-YC-S(P) | Human Anti-NTRK2 Recombinant Antibody (clone 4A6); scFv Fragment | Agonist, FuncS | Human scFv |
| HPAB-AP762-YC-S(P) | Human Anti-NTRK2 Recombinant Antibody (clone 4B12); scFv Fragment | Agonist, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP761-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4A6); Fab Fragment | Agonist, FuncS | Humanized Fab |
| HPAB-AP762-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4B12); Fab Fragment | Agonist, FuncS | Humanized Fab |
| HPAB-AP763-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone C1); Fab Fragment | Agonist, FuncS | Humanized Fab |
| HPAB-AP764-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4B12-17); Fab Fragment | Agonist | Humanized Fab |
| HPAB-AP765-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4B12-15); Fab Fragment | Agonist | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY99 | Human Anti-NTRK2 (clone 7-F1) scFv-Fc Chimera | IA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC548 | Recombinant Anti-NTRK2 Vesicular Antibody, EV Displayed (VS-0425-YC548) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5019 | Anti-NTRK2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5020 | Anti-Mouse NTRK2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5021 | Anti-Rat NTRK2 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Inhib, Cyt
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, IP, WB, IHC, IF, FuncS
Application: ELISA, Inhib, FC
Application: ELISA, FC, WB, Block
Application: ELISA, IHC, FC, IP, IF, BL
Application: ELISA, FC, Inhib
Application: ELISA, Neut, FuncS
Application: ELISA, Inhib, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
