Anti-PARP2 (clone W24V70) Recombinant Antibody Coupled Liposome (VS-1024-FY71)
CAT#: VS-1024-FY71
The application of anti-PARP2 antibodies conjugated with liposomes in the treatment of breast cancer is becoming increasingly important. PARP inhibitors have been approved for the treatment of HER2-negative breast cancer with germline BRCA mutations, especially when the cancer is locally advanced or metastatic. By conjugating antibodies with drug nanoparticles, therapeutic efficacy can be enhanced.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52003/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52003/122961_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52003/122961_A_9_3.jpg
Normal Tissue
Figure 4 Testis
Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52003/122961_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000129484-PARP2
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer
Product Composition
- Clone
- W24V70
- Antibody Type
- IgG
- Antibody Host
- Rabbit
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant rabbit antibody exhibits a highly specific binding affinity for human PARP2, indicating its potential utility in both research and therapeutic applications. This antibody has been engineered to recognize and bind to PARP2, an important enzyme involved in various cellular processes such as DNA repair and programmed cell death.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PARP2
- Introduction
- This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.
- Alternative Names
- Poly(ADP-Ribose) Polymerase 2; ADP-Ribosyltransferase (NAD+; Poly(ADP-Ribose) Polymerase)-Like 2; ADP-Ribosyltransferase Diphtheria Toxin-Like 2; Poly (ADP-Ribose) Polymerase Family; Member 2; NAD(+) ADP-Ribosyltransferase 2; Poly[ADP-Ribose] Synthase 2; EC 2.4.2.30; PADPRT-2; ADPRTL2; ADPRT-2
- Full Name
- Poly(ADP-Ribose) Polymerase 2
- Gene ID
- 10038
- UniProt ID
- Q9UGN5
- Sequence Similarities
- Belongs to the ARTD/PARP family.
- Cellular Localization
- Nucleus, Chromosome
- Post Translation Modifications
- Auto poly-ADP-ribosylated on serine residues, leading to dissociation of the PARP2-HPF1 complex from chromatin (PubMed:32939087, 34108479).
Poly-ADP-ribosylated by PARP1 (By similarity).
Acetylation reduces DNA binding and enzymatic activity. (Q9UGN5-PARP2_HUMAN)
Proteolytically cleaved by caspase-8 (CASP8) in response to apoptosis, leading to its inactivation. (Q9UGN5-PARP2_HUMAN)
Ubiquitination at Lys276, Lys348, and Lys480 (NX_Q9UGN5 [NX_Q9UGN5-1])
Modification sites at PhosphoSitePlus (Q9UGN5)
Glycosylation from GlyGen (Q9UGN5) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_005267304.1; XP_016876401.1; XP_047286825.1; XP_054189115.1; XP_054189116.1
- Function
- Specifically mediates formation of branched poly-ADP-ribosylation (PubMed:30104678).
Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF (PubMed:30104678).
In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex.
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Datasheet
MSDS
COA
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