Anti-PARP4 (clone W24V71) Recombinant Antibody Coupled Liposome (VS-1024-FY72)
CAT#: VS-1024-FY72
Liposomes conjugated with anti-PARP4 antibodies represent a promising advancement in breast cancer therapy, harnessing the specificity and affinity of these antibodies to deliver targeted treatment directly to tumor cells. This targeted approach not only enhances the therapeutic efficacy of the liposomal drugs but also plays a crucial role in modulating the tumor microenvironment, which can be detrimental to immune surveillance and response. By improving the conditions within the tumor microenvironment, these liposome-antibody complexes may significantly boost the immune system's capacity to recognize and eliminate cancer cells, potentially leading to improved patient outcomes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11739/89_F3_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human adrenal gland
Immunohistochemical staining of human adrenal gland shows strong nuclear and cytoplasmic positivity in cortical cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11739/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11739/28593_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11739/28593_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11739/28593_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11739/28593_A_6_6.jpg
Normal Tissue
Figure 7 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11739/28593_B_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11739/28593_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000102699-PARP4
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer
Product Composition
- Clone
- W24V71
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant monoclonal antibody derived from mice exhibits a remarkable and specific binding affinity towards human PARP4 (Poly(ADP-ribose) polymerase 4). This characteristic enables the antibody to selectively recognize and interact with the PARP4 protein, which plays a crucial role in various cellular processes, including DNA repair and regulation of gene expression.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PARP4
- Introduction
- This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.
- Alternative Names
- PH5P; p193; ARTD4; PARPL; VPARP; VWA5C; PARP-4; VAULT3; ADPRTL1
- Full Name
- Poly(ADP-Ribose) Polymerase Family Member 4
- Gene ID
- 143
- UniProt ID
- Q9UKK3
- Sequence Similarities
- Belongs to the ARTD/PARP family.
- Cellular Localization
- Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, spindle
- Post Translation Modifications
- Modification sites at PhosphoSitePlus ( Q9UKK3 )
Modification sites at neXtProt ( NX_Q9UKK3 )
Glycosylation from GlyGen (Q9UKK3) 4 sites, 1 O-linked glycan (4 sites)
- Protein Refseq
- NP_006428.2
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Datasheet
MSDS
COA
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See other products for "PARP4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1546CT | Recombinant Mouse anti-Human PARP4 Monoclonal antibody (Q204-20) | FC, IHC-FoFr, IHC-Fr, IHC-P, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2596 | Hi-Affi™ Recombinant Rabbit Anti-PARP4 Monoclonal Antibody (DS2596AB) | WB | IgG |
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