Anti-PD-L1 Antibody-Cytokine Fusion Protein, IgG (B60-55)-CCL1 (CAT#: ACFP-CQ0068)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PD-L1 IgG to CCL1. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PD-L1 as well as the biological activity of CCL1.


Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Target
  • PD-L1
  • Molecule Class
  • IgG-CCL1
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • B60-55
  • Cytokine 1
  • CCL1
  • Cytokines 1 Description
  • CCL1 (C-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CCL1 include Igg4-Related Sclerosing Cholangitis and Tolosa-Hunt Syndrome. Among its related pathways are PEDF Induced Signaling and Aryl Hydrocarbon Receptor. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Introduction
  • This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation.
  • Alternative Names
  • CD274; PD-L1; PDCD1L1; B7-H; Programmed Death Ligand 1; Programmed Cell Death 1 Ligand 1; PDCD1LG1; B7H1

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Humanized Antibody

CAT Product Name Application Type
TAB-0263CL Human Anti-CD274 Recombinant Antibody (TAB-0263CL) ELISA, WB, SPR, FuncS Humanized IgG
TAB-0264CL Human Anti-CD274 Recombinant Antibody (TAB-0264CL) ELISA, WB, SPR, ADCC, CDC, FuncS, Inhib Humanized IgG
TAB-0265CL Human Anti-CD274 Recombinant Antibody (TAB-0265CL) ELISA, WB, SPR, ADCC, CDC, FuncS Humanized IgG
TAB-0266CL Human Anti-CD274 Recombinant Antibody (TAB-0266CL) ELISA, WB, SPR, ADCC, CDC, FuncS Humanized IgG
TAB-0267CL Human Anti-CD274 Recombinant Antibody (TAB-0267CL) ELISA, WB, SPR, ADCC, CDC, FuncS Humanized IgG

Chimeric Antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-324CQ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3.C6) IHC-P, FC, Neut, ICC Mouse IgG2b, κ
NEUT-325CQ Human Anti-CD274 Recombinant Antibody (clone CBLS-206) Neut Human IgG1, κ
NEUT-326CQ Human Anti-CD274 Recombinant Antibody (clone CBLS-207) ELISA, Neut Human IgG1, κ
NEUT-327CQ Mouse Anti-CD274 Recombinant Antibody (clone MIH1) FC, FuncS, Neut, IHC, IF Mouse IgG1, κ
NEUT-330CQ Rat Anti-CD274 Recombinant Antibody (clone MIH5) FC, FuncS, Neut, IHC-Fr, WB Rat IgG2a, λ

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-417CQ Afuco™ Anti-CD274 ADCC Recombinant Antibody (Durvalumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody
AFC-TAB-418CQ Afuco™ Anti-CD274 ADCC Recombinant Antibody (Atezolizumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, BL ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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