Anti-PDGFB Antibody Prodrug, Protease Activated (VS-1025-YC106)
CAT#: VS-1025-YC106
The Anti-PDGFB Antibody Prodrug, Protease Activated (VS-1025-YC106) is an antibody prodrug comprised of a recombinant human antibody targeting human PDGFB, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to PDGFB protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to PDGFB effectively. PDGFB (Platelet-Derived Growth Factor B) is a growth factor that acts as a potent stimulator of the tumor microenvironment, specifically by promoting the proliferation of pericytes and fibroblasts. Secreted by tumor cells, PDGFB recruits and activates these stromal components, leading to the formation of a dense, supportive connective tissue and contributing to the metastatic process.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/1592_D1_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human caudate
Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in granular pattern in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/ihc_selected.jpg
Normal Tissue
Figure 3 Placenta
Cytotrophoblasts Staining: Medium Intensity: Moderate Quantity:>75% Endothelial cells Staining: High Intensity: Strong Quantity:>75% Hofbauer cells Staining: Medium Intensity: Moderate Quantity:>75% Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_1_7.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_9_8.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18341/40769_A_5_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (A-431, EFO-21, HUVEC TERT2, SK-BR-3, TIME)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000100311-PDGFB
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human PDGFB
- Target
- PDGFB
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.
- Alternative Names
- SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2
- Gene ID
- 5155
- UniProt ID
- P01127
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Datasheet
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COA
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| CAT | Product Name | Application | Type |
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| PFBL-297 | Human Anti-PDGFB Recombinant Antibody Fab Fragment (PFBL-297) | WB, ELISA, FuncS | Human Fab |
| HPAB-0385-CN-F(E) | Human Anti-PDGFB Recombinant Antibody; Fab Fragment (HPAB-0385-CN-F(E)) | ELISA, FC, IF, Block | Human Fab |
| HPAB-0386-CN-F(E) | Rat Anti-PDGFB Recombinant Antibody; Fab Fragment (HPAB-0386-CN-F(E)) | ELISA, Block | Rat Fab |
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