Anti-PDGFRL (clone W24V148) Recombinant Antibody Coupled Liposome (VS-1024-FY148)
CAT#: VS-1024-FY148
The innovative use of anti-PDGFRL antibody-conjugated liposomes in colorectal cancer treatment represents a significant advancement in drug delivery systems. By specifically targeting the PDGFRL receptor, these liposomes not only ensure a higher bioavailability of therapeutic agents but also improve their selectivity towards cancer cells, minimizing off-target effects. This targeted approach facilitates the endocytosis of drugs into tumor cells, significantly enhancing their anti-tumor activity and potentially leading to more effective treatment outcomes for patients suffering from colorectal cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm, nucleoli & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52801/if_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (AN3-CA, BJ hTERT+, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104213-PDGFRL
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More Infomation
Specifications
- Potential Clinical Applications
- Colorectal cancer
Product Composition
- Clone
- W24V148
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that has been meticulously engineered to selectively bind to the Platelet-Derived Growth Factor Receptor-Like (PDGFRL). This innovative antibody is developed using advanced biotechnological techniques, allowing for high specificity and affinity towards PDGFRL, a receptor involved in various biological processes, including cell proliferation, differentiation, and angiogenesis.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PDGFRL
- Introduction
- This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.
- Alternative Names
- PDGFRL; Platelet-Derived Growth Factor Receptor-Like Protein; PDGRL; Platelet-Derived Growth Factor Receptor-Like; Platelet-Derived Growth Factor-Beta-Like Tumor Suppressor; PDGFR-Like Protein
- Full Name
- Platelet Derived Growth Factor Receptor Like
- Gene ID
- 5157
- UniProt ID
- Q15198
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn132 and Asn219 ( NX_Q15198 [NX_Q15198-1] )
Modification sites at PhosphoSitePlus ( Q15198 )
Glycosylation from GlyConnect PGFRL_HUMAN (1609)
Glycosylation from GlyGen (Q15198) 2 sites, 3 N-linked glycans (1 site)
- Protein Refseq
- NP_001359002.1; NP_006198.1
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Datasheet
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COA
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See other products for "PDGFRL"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3930z | Mouse Anti-PDGFRL Recombinant Antibody (clone 37B7) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1600 | Anti-PDGFRL Immunohistochemistry Kit | IHC |
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