Rabbit Anti-PDZK1 Recombinant Antibody (clone R07-2A6)
CAT#: VS3-FY1823
Clone R07-2A6 is a rabbit recombinant monoclonal antibody that demonstrates specific reactivity with human PDZK1. The antibody is recommended for detection of PDZK1 protein by WB, IP. The PDZK1 antibody is guaranteed for western blot analysis of PDZK1 in T4D7, Caco2 lysates.
Gene Expression
Tested Data
Subcellular Location
Figure 1 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to nucleoplasm, cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6155/1789_C5_32_selected.jpg
Normal Tissue
Figure 2 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6155/20347_A_8_4.jpg
Normal Tissue
Figure 3 Kidney
Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6155/20347_A_8_5.jpg
Normal Tissue
Figure 4 Small intestine
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Gradient Gradient: Ascending Enterocytes - Microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6155/20347_A_5_2.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (RPTEC TERT1, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000174827-PDZK1
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WB
Figure 1 Anti-PDZK1 Antibody (VS3-FY1823) in WB.
The PDZK1 expression in T4D7, Caco2 lysates were detected using the anti-PDZK1 by western blot assay.
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Specifications
- Immunogen
- Synthetic peptide of human PDZK1
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human PDZK1
- Species Reactivity
- Human
- Clone
- R07-2A6
- Applications
- Western Blot, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 57 kDa, while the observed molecular weight stands at 70 kDa.
- Related Disease
- Gout and Inflammatory Diarrhea
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunoprecipitation: 1/20
Target
- Alternative Names
- PDZ Domain Containing 1; Na/Pi Cotransporter C-Terminal-Associated Protein 1; Sodium-Hydrogen Exchanger Regulatory Factor 3; CFTR-Associated Protein Of 70 KDa; NaPi-Cap1; NHERF-3; NHERF3; CAP70
- Gene ID
- 5174
- UniProt ID
- Q5T2W1
- Sequence Similarities
- Belongs to the NHER family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (Q5T2W1)
Modification sites at neXtProt (NX_Q5T2W1)
- Protein Refseq
- XP_024303387.1; XP_024303388.1; XP_047278483.1; XP_047278484.1; XP_047278485.1
- Function
- May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "PDZK1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3581z | Mouse Anti-PDZK1 Recombinant Antibody (clone 35B5) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| MOB-1333CT | Recombinant Mouse anti-Human PDZK1 Monoclonal antibody (1A2) | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2654 | Hi-Affi™ Recombinant Rabbit Anti-PDZK1 Monoclonal Antibody (DS2654AB) | FC, ICC, IF, IHC-P, IP, WB | IgG |
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