Human Anti-PERP Recombinant Antibody Hexamer (VS-0924-YC143), CDC Enhanced (CAT#: VS-0924-YC143)
Human Anti-PERP Antibody: This is an antibody that specifically targets the PERP protein in humans.
Hexameric IgG1: The antibody is in the form of an IgG1 hexamer, meaning it consists of six IgG1 molecules linked together.
Hexamerization-Enhancing Mutations: These are specific mutations engineered into the antibody to promote the formation of hexamers.
Enhanced CDC Activity: The primary function of this hexameric antibody is to enhance complement-dependent cytotoxicity, a mechanism where antibodies direct the immune system to destroy target cells.
Optimal C1q Binding: The hexamer formation facilitates the binding of C1q, a component of the complement system, thereby enhancing the CDC effect.

(Cells in corneal layer
Staining:High
Intensity: Strong
Quantity:>75%
Cells in granular layer
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22269/51287_B_9_1.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112378-PERP
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Antibody hexamer
- Specificity
- Human PERP
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- FC, ADCC, CDC
- Conjugate
- None
- Related Disease
- Diseases expressing a polypeptide encoded by the PERP gene such as cancers
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- PERP; PERP, TP53 apoptosis effector; THW; KCP1; PIGPC1; KRTCAP1; dJ496H19.1; p53 apoptosis effector related to PMP-22; KCP-1; 1110017A08Rik; transmembrane protein THW; p53-induced protein PIGPC1; keratinocyte associated protein 1; keratinocyte-associated protein 1; keratinocytes associated protein 1; p53 apoptosis effector related to PMP22
- Gene ID
- 64065
- UniProt ID
- Q96FX8
- Long Name
- P53 Apoptosis Effector Related To PMP22
- Sequence Similarities
- Belongs to the TMEM47 family.
- Cellular Localization
- Cell junction, desmosome {ECO:0000250 UniProtKB:Q9JK95}
Cell membrane; Multi-pass membrane protein {ECO:0000269 PubMed:25486861, 30321533, 31898316 | ECO:0000255}
Cytoplasm {ECO:0000269 PubMed:25486861}
- Protein Refseq
- NP_071404.2
- Function
- Belongs to the TMEM47 family.
Downloads
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See other products for "PERP"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1017CL | Anti-Human PERP Recombinant Antibody (KM3411) | FC | |
TAB-1017CL-S(P) | Anti-Human PERP Recombinant Antibody scFv Fragment (KM3411) | SDS-PAGE, FC | |
TAB-1017CL-F(E) | Anti-Human PERP Recombinant Antibody Fab Fragment (KM3411) | SDS-PAGE, FC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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