Human Anti-PERP Recombinant Antibody Hexamer (VS-0924-YC143), CDC Enhanced
CAT#: VS-0924-YC143
Human Anti-PERP Antibody: This is an antibody that specifically targets the PERP protein in humans.
Hexameric IgG1: The antibody is in the form of an IgG1 hexamer, meaning it consists of six IgG1 molecules linked together.
Hexamerization-Enhancing Mutations: These are specific mutations engineered into the antibody to promote the formation of hexamers.
Enhanced CDC Activity: The primary function of this hexameric antibody is to enhance complement-dependent cytotoxicity, a mechanism where antibodies direct the immune system to destroy target cells.
Optimal C1q Binding: The hexamer formation facilitates the binding of C1q, a component of the complement system, thereby enhancing the CDC effect.
Gene Expression
Normal Tissue
Figure 1 Skin
Cells in corneal layer
Staining:High
Intensity: Strong
Quantity:>75%
Cells in granular layer
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22269/51287_B_9_1.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (hTCEpi)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112378-PERP
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Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Antibody hexamer
- Specificity
- Human PERP
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- FC, ADCC, CDC
- Conjugate
- None
- Related Disease
- Diseases expressing a polypeptide encoded by the PERP gene such as cancers
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- PERP; PERP, TP53 apoptosis effector; THW; KCP1; PIGPC1; KRTCAP1; dJ496H19.1; p53 apoptosis effector related to PMP-22; KCP-1; 1110017A08Rik; transmembrane protein THW; p53-induced protein PIGPC1; keratinocyte associated protein 1; keratinocyte-associated protein 1; keratinocytes associated protein 1; p53 apoptosis effector related to PMP22
- Gene ID
- 64065
- UniProt ID
- Q96FX8
- Long Name
- P53 Apoptosis Effector Related To PMP22
- Sequence Similarities
- Belongs to the TMEM47 family.
- Cellular Localization
- Cell junction, desmosome {ECO:0000250 UniProtKB:Q9JK95}
Cell membrane; Multi-pass membrane protein {ECO:0000269 PubMed:25486861, 30321533, 31898316 | ECO:0000255}
Cytoplasm {ECO:0000269 PubMed:25486861}
- Protein Refseq
- NP_071404.2
- Function
- Belongs to the TMEM47 family.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PERP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1017CL | Anti-Human PERP Recombinant Antibody (KM3411) | FC | |
| TAB-1017CL-S(P) | Anti-Human PERP Recombinant Antibody scFv Fragment (KM3411) | SDS-PAGE, FC | |
| TAB-1017CL-F(E) | Anti-Human PERP Recombinant Antibody Fab Fragment (KM3411) | SDS-PAGE, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1018CL | Anti-Human PERP Recombinant Antibody (KM3481) | FC, ADCC, CDC, FuncS | Chimeric antibody (mouse/human) |
| TAB-1018CL-S(P) | Anti-Human PERP Recombinant Antibody scFv Fragment (KM3481) | SDS-PAGE, FC | Chimeric antibody (mouse/human) |
| TAB-1018CL-F(E) | Anti-Human PERP Recombinant Antibody Fab Fragment (KM3481) | SDS-PAGE, FC | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2663 | Hi-Affi™ Recombinant Rabbit Anti-PERP Monoclonal Antibody (DS2663AB) | WB, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1209-CN | Recombinant Rabbit Anti-PERP Monoclonal Antibody (JU04-51) | WB, IHC | Rabbit IgG |
| VS13-YC895 | Rabbit Anti-PERP Recombinant Antibody (VS13-YC895) | WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC278 | Recombinant Anti-PERP Vesicular Antibody, EV Displayed (VS-0425-YC278) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5314 | Anti-PERP Immunohistochemistry Kit | IHC |
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