Recombinant Human Anti-PfCSP Antibody (mab317) (CAT#: PABC-491)
This product is a recombinant Human antibody that can recognize PfCSP. The antibody binds to the NANP repeat region in a recombinant CSP construct. mab317 requires a minimum of two NANP repeats.
Specific Inquiry
BLI
Figure 1 Human Anti-PfCSP Antibody (mab317) in BLI.
Binding studies to assess dual specificity for the junctional and NANP epitopes. Biolayer Interferometry (BLI) was used to measure the kinetics of binding for Fab317, Fab667 and Fab668 to either the NPNANPNANPNANPNA (NANP) peptide or the KQPADGNPDPNANPNV (junctional) peptide.
Oyen, D., Torres, J. L., Aoto, P. C., Flores-Garcia, Y., Binter, Š., Pholcharee, T., ... & Wilson, I. A. (2020). Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein. PLoS pathogens, 16(3), e1008373.
IF
Figure 2 Human Anti-PfCSP Antibody (mab317) in IF.
In vivo mice protection studies. Representative mAb immunofluorescence reactivity (green) with Pf sporozoites. Phase-contrast and fluorescence channels are shown.
Pholcharee, T. , Oyen, D. , Torres, J. L. , Flores-Garcia, Y. , & Wilson, I. A. . (2019). Diverse antibody responses to conserved structural motifs in plasmodium falciparum circumsporozoite protein. Journal of Molecular Biology, 432(4).
ELISA
Figure 3 Human Anti-PfCSP Antibody (mab317) in ELISA.
Binding of different concentrations of mAbs to PfSPZ in an ELISA. OD405 nm = optical density at 405 nm. Error bars represent standard deviation (SD; N = 2).
Pholcharee, T. , Oyen, D. , Torres, J. L. , Flores-Garcia, Y. , & Wilson, I. A. . (2019). Diverse antibody responses to conserved structural motifs in plasmodium falciparum circumsporozoite protein. Journal of Molecular Biology, 432(4).
Specifications
- Immunogen
- P. berghei chimeric sporozoites expressing P. falciparum CSP (3D7 strain)
- Host Species
- Human
- Type
- Human IgG1, κ
- Specificity
- PfCSP
- Species Reactivity
- P. falciparum
- Clone
- mab317
- Applications
- ELISA, FuncS
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Target
- Alternative Names
- P. falciparum circumsporozoite protein; PfCSP
- UniProt ID
- P02893
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv Antibody Products
Fab Antibody Products
IgM Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0228-CN-S(P) | Recombinant Mouse Anti-PfCSP Antibody scFv Fragment (2A10) | ELISA, IB | Mouse scFv |
| PSBC-306 | Recombinant Human Anti-PfCSP Antibody scFv Fragment (1210) | ELISA | Human scFv |
| PSBC-372 | Human Anti-PfCSP Recombinant Antibody; scFv Fragment (PSBC-372) | ELISA, IF, Inhib | Human scFv |
| PSBC-373 | Human Anti-PfCSP Recombinant Antibody; scFv Fragment (PSBC-373) | ELISA, IF, Inhib | Human scFv |
| FAMAB-0276WJ-S(P) | Human Anti-PfCSP Recombinant Antibody (clone MGG3); scFv Fragment | ELISA, WB, Neut | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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