Recombinant Human Anti-PfCSP Antibody (mab317) (CAT#: PABC-491)
This product is a recombinant Human antibody that can recognize PfCSP. The antibody binds to the NANP repeat region in a recombinant CSP construct. mab317 requires a minimum of two NANP repeats.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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BLI
Figure 1 Human Anti-PfCSP Antibody (mab317) in BLI.
Binding studies to assess dual specificity for the junctional and NANP epitopes. Biolayer Interferometry (BLI) was used to measure the kinetics of binding for Fab317, Fab667 and Fab668 to either the NPNANPNANPNANPNA (NANP) peptide or the KQPADGNPDPNANPNV (junctional) peptide.
Oyen, D., Torres, J. L., Aoto, P. C., Flores-Garcia, Y., Binter, Š., Pholcharee, T., ... & Wilson, I. A. (2020). Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein. PLoS pathogens, 16(3), e1008373.
IF
Figure 2 Human Anti-PfCSP Antibody (mab317) in IF.
In vivo mice protection studies. Representative mAb immunofluorescence reactivity (green) with Pf sporozoites. Phase-contrast and fluorescence channels are shown.
Pholcharee, T. , Oyen, D. , Torres, J. L. , Flores-Garcia, Y. , & Wilson, I. A. . (2019). Diverse antibody responses to conserved structural motifs in plasmodium falciparum circumsporozoite protein. Journal of Molecular Biology, 432(4).
ELISA
Figure 3 Human Anti-PfCSP Antibody (mab317) in ELISA.
Binding of different concentrations of mAbs to PfSPZ in an ELISA. OD405 nm = optical density at 405 nm. Error bars represent standard deviation (SD; N = 2).
Pholcharee, T. , Oyen, D. , Torres, J. L. , Flores-Garcia, Y. , & Wilson, I. A. . (2019). Diverse antibody responses to conserved structural motifs in plasmodium falciparum circumsporozoite protein. Journal of Molecular Biology, 432(4).
Specifications
- Immunogen
- P. berghei chimeric sporozoites expressing P. falciparum CSP (3D7 strain)
- Host Species
- Human
- Type
- Human IgG1, κ
- Specificity
- PfCSP
- Species Reactivity
- P. falciparum
- Clone
- mab317
- Applications
- ELISA, FuncS
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Target
- Alternative Names
- P. falciparum circumsporozoite protein; PfCSP
- UniProt ID
- P02893
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0228-CN | Recombinant Mouse Anti-PfCSP Antibody (2A10) | ELISA, IB, IF, WB | Mouse IgG |
| PABC-306 | Recombinant Human Anti-PfCSP Antibody (1210) | ELISA, Inhib | Human IgG |
| PABC-372 | Human Anti-PfCSP Recombinant Antibody (PABC-372) | ELISA, IF, Inhib | Human IgG |
| PABC-373 | Human Anti-PfCSP Recombinant Antibody (PABC-373) | ELISA, IF, Inhib | Human IgG |
| VS-0923-XY20 | Recombinant Human Anti-PfCSP Antibody (clone iGL-CIS43.D3) | ELISA, FC, BLI | Human IgG |
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