Human Anti-PIV3 Prefusion Recombinant Antibody (PABJ-0161) (CAT#: PABJ-0161)
This product is a Human antibody that recognizes PIV3 Prefusion.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- PIV3 Prefusion
- Species Reactivity
- PIV3
- Applications
- ELISA, Neut
Product Property
- Purification
- Protein A/G Purified
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Neutralization.
Target
- Alternative Names
- Human respirovirus 3 Prefusion; PIV3; Prefusion; Human respirovirus 3; hPIV3
Related Resources
Marcink, Tara C., et al. "Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms." Science Advances 9.6 (2023): eade2727. https://doi.org/10.1126/sciadv.ade2727
The study aims to investigate the structure of the fusion complex of human parainfluenza virus 3 (HPIV3) using cryo-electron tomography. It specifically focuses on the interaction between the hemagglutinin-neuraminidase (HN) and fusion (F) proteins, which are essential for viral entry into host cells. By visualizing these proteins at subnanometer resolution, the researchers were able to detail how HN and F proteins remain in a quiescent state on the viral surface until activation and how HN facilitates F's role in the fusion process. This research provides insights into the mechanisms of viral entry and potential targets for antiviral therapies.
Creative Biolabs contributed to this research by supplying the PIA174 antibody Fab fragment (Cat# PABJ-0161-F(E)) and full antibody (Cat# PABJ-0161) used in the study. The catalog number for these products is not explicitly mentioned in the document. These antibodies were crucial for structural studies, allowing the researchers to stabilize and visualize the prefusion F complex and understand the precise interaction between HN and F proteins. The use of these antibodies facilitated the detailed examination of the viral fusion mechanism, which is essential for developing strategies to prevent viral entry into host cells.
More Infomation
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0161-S(P) | Human Anti-PIV3 Prefusion Recombinant Antibody scFv Fragment (PABJ-0161-S(P)) | ELISA, Neut | Human scFv |
Customer Reviews and Q&As
Customer Review
Q&As
Rachel Adams
Excellent for PIV3 Research
Excellent for PIV3 Research
The Anti-PIV3 Prefusion Recombinant Antibody has been excellent for our PIV3 studies. Its quality is top-notch, providing clear and reliable results. This product has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.
25.Apr,23
Michael Clark
Effective and Dependable
Effective and Dependable
We incorporated this antibody into our PIV3 protocols, and it has been a great asset. The consistency and reliability are impressive, allowing for accurate and reproducible results. The reliable performance has made it an invaluable tool in our lab.
07.Aug,22
Laura Harris
Consistent High-Quality Results
Consistent High-Quality Results
This antibody has proven to be consistent and high-quality in our PIV3 procedures. The reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The consistent performance has greatly enhanced our data quality.
03.Jun,21
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# PABJ-0161, RRID: AB_3111610)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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