Anti-PRDX2 (clone W24V122) Recombinant Antibody Coupled Liposome (VS-1024-FY124) (CAT#: VS-1024-FY124)

• Potential Clinical Applications
• Glioma

• Clone
• W24V122

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that was designed to specifically target and bind to human Peroxiredoxin 2 (PRDX2). PRDX2 is a crucial antioxidant enzyme that plays a vital role in protecting cells from oxidative stress, and this antibody can be instrumental in various research applications. By utilizing this specific antibody, scientists can effectively study the functions and mechanisms of PRDX2 in human health and disease.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• PRDX2

• Introduction
• This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13.

• Alternative Names
• PRDX2; NKEFB; TDPX1; Peroxiredoxin-2; Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1

• Full Name
• Peroxiredoxin 2

• Gene ID
• 7001

• UniProt ID
• P32119

• Sequence Similarities
• Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

• Cellular Localization
• Cytoplasm

• Post Translation Modifications
• The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.

• Protein Refseq
• NP_005800.3

• Function
• Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2.

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