Mouse Anti-PRG3 Recombinant Antibody Hexamer (VS-0924-YC144), CDC Enhanced
CAT#: VS-0924-YC144
The product is a mouse anti-PRG3 antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human PRG3 and features hexamerization-enhancing mutations. These mutations foster hexamer formation, facilitating optimal C1q binding, and thereby boosting CDC activity.
Specifications
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human PRG3
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- FC, ADCC, CDC
- Conjugate
- None
- Related Disease
- Hepatocellular carcinoma, lung cancer, colon cancer, and glioblastoma
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- PRG3; proteoglycan 3; MBP2; MBPH; prepro-MBPH; prepro-major basic protein homolog; eosinophil major basic protein homolog
- Gene ID
- 10394
- UniProt ID
- Q9Y2Y8
- Long Name
- Proteoglycan 3, Pro Eosinophil Major Basic Protein 2
- Cellular Localization
- Cytoplasmic granule
- Protein Refseq
- NP_006084.2
- Function
- Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.
In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC145 | Human Anti-PRG3 Recombinant Antibody Hexamer (VS-0924-YC145), CDC Enhanced | CDC | Antibody hexamer |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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