Human Anti-Prothrombin Recombinant Antibody (clone P13) (CAT#: FAMAB-0343JF)
Recombinant monoclonal antibody specially binds to prothrombin. This human anti-prothrombin antibody (P13) can be widely used in the diagnosis of antiphospholipid syndrome patients.
Specific Inquiry
IHC
Figure 1 Immunohistochemical studies of DCP in human HCC.
Serum DCP levels correlated with staining intensity of DCP.
Murata, K., Suzuki, H., Okano, H., Oyamada, T., Yasuda, Y., & Sakamoto, A. (2009). Cytoskeletal changes during epithelial-to-fibroblastoid conversion as a crucial mechanism of des-γ-carboxy prothrombin production in hepatocellular carcinoma. International journal of oncology, 35(5), 1005-1014.
IF
Figure 2 Immunofluorescent studies of DCP production.
DCP production in both cells (paired t-test) without any inhibitory effects of vitamin K2 (100 nM). Values are means ± SEM.
Murata, K., Suzuki, H., Okano, H., Oyamada, T., Yasuda, Y., & Sakamoto, A. (2009). Cytoskeletal changes during epithelial-to-fibroblastoid conversion as a crucial mechanism of des-γ-carboxy prothrombin production in hepatocellular carcinoma. International journal of oncology, 35(5), 1005-1014.
WB
Figure 3 DCP production in cells with reduced E-cadherin expression.
DCP production (red) was observed clearly
in TPA-treated cells along with reduced E-cadherin expression.
Murata, K., Suzuki, H., Okano, H., Oyamada, T., Yasuda, Y., & Sakamoto, A. (2009). Cytoskeletal changes during epithelial-to-fibroblastoid conversion as a crucial mechanism of des-γ-carboxy prothrombin production in hepatocellular carcinoma. International journal of oncology, 35(5), 1005-1014.
ELISA
Figure 4 TPA induced DCP production in a dose-dependent manner in HepG2.
TGF-β1 also induced DCP production in a dose-dependent manner in HepG2.
Murata, K., Suzuki, H., Okano, H., Oyamada, T., Yasuda, Y., & Sakamoto, A. (2009). Cytoskeletal changes during epithelial-to-fibroblastoid conversion as a crucial mechanism of des-γ-carboxy prothrombin production in hepatocellular carcinoma. International journal of oncology, 35(5), 1005-1014.
Specifications
- Host Species
- Human
- Derivation
- Human phage display Fab library
- Type
- Human IgG
- Specificity
- Human Prothrombin
- Species Reactivity
- Human
- Clone
- P13
- Applications
- WB, ELISA, IHC, IF
- Related Disease
- Thrombosis, Recurrent fetal loss, Thrombocytopenia
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The Prothrombin antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Immunofluorescence.
Target
- Alternative Names
- Prothrombin
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0441MZ | Chicken Anti-Prothrombin Polyclonal IgY | WB | Chicken antibody |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP223-YC | Recombinant Llama Anti-Prothrombin Single Domain Antibody (HPAB-AP223-YC) | ELISA, FuncS | |
| HPAB-AP224-YC | Recombinant Llama Anti-Prothrombin Single Domain Antibody (HPAB-AP224-YC) | ELISA, FuncS | |
| HPAB-AP225-YC | Recombinant Llama Anti-Prothrombin Single Domain Antibody (HPAB-AP225-YC) | ELISA, FuncS | |
| HPAB-AP226-YC | Recombinant Llama Anti-Prothrombin Single Domain Antibody (HPAB-AP226-YC) | ELISA, FuncS |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0343JF-F(E) | Human Anti-Prothrombin Recombinant Antibody (clone P13); Fab Fragment | ELISA, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0343JF-S(P) | Human Anti-Prothrombin Recombinant Antibody (clone P13); scFv Fragment | ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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