AbPlus™ Anti-PSEN1 Magnetic Beads (VS-0724-YC1278) (CAT#: VS-0724-YC1278)
The AbPlus Anti-PSEN1 Magnetic Beads (VS-0724-YC1278) is an innovative affinity resin which is bound with anti-PSEN1 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of PSEN1 protein under native and denaturing conditions.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67496/1462_C6_5_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67496/1462_C6_5_selected.jpg

Figure 2 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity with a granular pattern in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/ihc_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity with a granular pattern in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/ihc_selected.jpg

Figure 3 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_B_7_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_B_7_5.jpg

Figure 4 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_3.jpg

Figure 5 Liver
(Hepatocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_4.jpg
(Hepatocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_4.jpg

Figure 6 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_5.jpg

Figure 7 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_4_6.jpg
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_4_6.jpg

Figure 8 Lymph node
(Germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_8.jpg
(Germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_8.jpg

Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000080815-PSEN1/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000080815-PSEN1/subcellular
Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-PSEN1 specific antibody
- Target
- PSEN1
- Immunogen
- Recombinant human PR-Set7/KMT5A, aa 195-352.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation. [provided by RefSeq, May 2016]
- Alternative Names
- Lysine Methyltransferase 5A; SET Domain Containing (Lysine Methyltransferase) 8; Lysine (K)-Specific Methyltransferase 5A; Histone-Lysine N-Methyltransferase KMT5A; PR/SET Domain-Containing Protein 07; SET Domain-Containing Protein 8; Lysine N-Methyltransferase 5A; Lysine-Specific Methylase 5A; H4-K20-HMTase KMT5A; EC 2.1.1.43; PR/SET07; PR-Set7; SETD8;
- Gene ID
- 387893
- UniProt ID
- Q9NQR1
Downloads
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1791z | Mouse Anti-PSEN1 Recombinant Antibody (clone 35G2) | WB, ELISA, IF, IP | Mouse IgG1, κ |
MOB-1686CT | Recombinant Mouse anti-Human PSEN1 Monoclonal antibody (45-5D4) | IP, WB | |
VS3-FY1204 | Recombinant Rabbit Anti-PSEN1 Antibody (clone R05-4D4) | WB, ICC, IF, IP | Rabbit IgG |
VS3-XY3477 | Rabbit Anti-PSEN1 Recombinant Antibody (clone R01-3J6) | WB, FC | Rabbit IgG |
VS3-WK1980 | Rabbit Anti-PSEN1 (pS310) Recombinant Antibody (clone R07-6E3) | WB | Rabbit IgG |
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