Anti-PTK7 Antibody Prodrug, Protease Activated (VS-1025-YC185)
CAT#: VS-1025-YC185
The Anti-PTK7 Antibody Prodrug, Protease Activated (VS-1025-YC185) is an antibody prodrug comprised of a recombinant human antibody targeting human and Monkey PTK7, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to PTK7 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to PTK7 effectively. PTK7 (Protein Tyrosine Kinase 7) is a receptor tyrosine kinase that is catalytically inactive but acts as an oncogene by regulating Wnt signaling and cell migration. Its overexpression is strongly associated with metastasis and poor prognosis in many cancers, making it a target for antibody-drug conjugates (ADCs).
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human and Monkey PTK7
- Target
- PTK7
- Species Reactivity
- Human, Monkey
- Isotype
- IgG4, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion.
- Alternative Names
- CCK4; CCK-4
- Gene ID
- 5754
- UniProt ID
- Q13308
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0356CT | Recombinant Mouse anti-Human PTK7 Monoclonal antibody (EML650) | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0027-LS | Human Anti-PTK7 Recombinant Antibody (HPAB-0027-LS) | ELISA, IB, FC, FuncS | Humanized IgG4 κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0028-LS | Human Anti-PTK7 Recombinant Antibody (HPAB-0028-LS) | ELISA, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0029-LS | Human Anti-PTK7 Recombinant Antibody (HPAB-0029-LS) | ELISA, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030-LS | Human Anti-PTK7 Recombinant Antibody (HPAB-0030-LS) | ELISA, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0027-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0027-LS-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0028-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0028-LS-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0029-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0029-LS-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0030-LS-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0031-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0031-LS-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0027-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0027-LS-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0028-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0028-LS-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0029-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0029-LS-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0030-LS-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0031-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0031-LS-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY170 | Human Anti-PTK7 scFv-Fc Chimera (VS-0425-FY170) | WB, ELISA, IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC670 | Recombinant Anti-PTK7 Vesicular Antibody, EV Displayed (VS-0425-YC670) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5851 | Anti-PTK7 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5852 | Anti-Rat PTK7 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC289 | SmartAb™ Recombinant Anti-PTK7 pH-dependent Antibody (VS-0825-YC289) | ELISA, IB, FC | Human IgG4 kappa |
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