Recombinant Mouse Anti-PTPRB Monoclonal Antibody (2-A2)
CAT#: MRO-1296-CN
This antibody is a mouse monoclonal antibody that is capable of binding to PTPRB.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67868/1717_A6_22_cr57f514fc87452_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4782/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67868/1315_H7_2_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67868/1287_H7_1_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4782/11835_B_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4782/11671_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4782/11671_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000127329-PTPRB
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human
- Species Reactivity
- Human, Mouse
- Clone
- 2-A2
- Applications
- Used for immunoassay techniques such as: Immunofluorescence; Immunohistochemistry
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G affinity purified
- Format
- Liquid
- Buffer
- 1*TBS, pH 7.4, 1% BSA, 40% Glycerol
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Target
REVIEWS AND Q&AS
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Precision in Target Detection
Using the Anti-PTPRB Antibody has greatly enhanced my ability to detect specific protein expressions in cancer tissues. Its specificity and reproducibility are unmatched, making it a critical component of my laboratory work focused on tumor microenvironments and potential therapeutic targets.
Reliable Cancer Research Ally
In our cancer biomarker studies, the Anti-PTPRB Antibody has proven to be an excellent resource. Its ability to clearly delineate PTPRB's expression in various cancerous tissues aids in the precise classification of tumor types and their progression.
Molecular Pathways Delineation
This antibody has empowered our research by allowing us to delve deeper into PTPRB-mediated pathways. We've discovered new interactions and mechanisms that were previously challenging to demonstrate, especially in the context of metabolic pathway research.
Q&As
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How does Anti-PTPRB contribute to oncology research?
A: This antibody is valuable in oncology research as it targets PTPRB, a protein tyrosine phosphate receptor linked to tumor progression and angiogenesis. Understanding its role could uncover pathways involved in cancer progression and potential therapeutic targets.
-
What is the significance of PTPRB in cellular functions?
A: PTPRB plays a crucial role in regulating cell growth, differentiation, and signaling pathways. It is essential for maintaining cellular processes and can impact vascular development and cell-to-cell interactions, making it vital for research in developmental biology and vascular diseases.
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What diseases are associated with dysregulation of PTPRB?
A: Dysregulation of PTPRB is associated with various diseases such as cancer, vascular malformations, and potentially metabolic disorders. Studying its pathways offers insights into these conditions' pathogenesis.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "PTPRB"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3104z | Mouse Anti-PTPRB Recombinant Antibody (clone 7C10) | ICC, IF | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-292CT | Human Anti-PTPRB Recombinant Antibody (TAB-292CT) | ELISA, FC | Human IgG |
| TAB-292CT-S(P) | Human Anti-PTPRB Recombinant Antibody; scFv Fragment (TAB-292CT-S(P)) | ELISA, FC | Human scFv |
| TAB-292CT-F(E) | Human Anti-PTPRB Recombinant Antibody; Fab Fragment (TAB-292CT-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS1-YJ199 | Mouse Anti-Ptprb Recombinant Antibody (clone 122.2) | IF, ICC, WB, IP | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC185 | Recombinant Anti-PTPRB Vesicular Antibody, EV Displayed (VS-0425-YC185) | ELISA, FC, Cell-uptake |
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