Rabbit Anti-RAB8A Recombinant Antibody (VS13-YC972) (CAT#: VS13-YC972)

• Immunogen
• Recombinant human RAB8A, aa 151-200.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human RAB8A

• Species Reactivity
• Human

• Applications
• WB

• Conjugate
• NONE

• Related Disease
• Microvillus Inclusion Disease and Open-Angle Glaucoma

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.

• Preservative
• 0.05% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/500

• Alternative Names
• RAB8A, Member RAS Oncogene Family; Mel Transforming Oncogene (Derived From Cell Line NK14); Oncogene C-Mel; RAB8; MEL; Mel Transforming Oncogene (Derived From Cell Line NK14)- RAB8 Homolog; Mel Transforming Oncogene (RAB8 Homolog); Ras-Associated Protein RAB8; Ras-Related Protein Rab-8A;

• Gene ID
• 4218

• UniProt ID
• P61006

• Long Name
• RAB8A, Member RAS Oncogene Family

• Sequence Similarities
• Belongs to the small GTPase superfamily. Rab family.

• Cellular Localization
• Cell membrane; Golgi apparatus; Recycling endosome membrane; Cytoplasm; Centriole

• Protein Refseq
• NP_005361.2

• Function
• The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
  Regulates the compacted morphology of the Golgi.
  Together with MYO5B and RAB11A participates in epithelial cell polarization.
  Also involved in membrane trafficking to the cilium and ciliogenesis.
  Together with MICALL2, may also regulate adherens junction assembly (By similarity).
  May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity).

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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