Mouse Anti-RB1CC1 Recombinant Antibody (clone 2C9A11) (CAT#: VS7-0425-WR768)

• Immunogen
• Recombinant human RB1CC1 (AA: 148-244) fragment expressed in E. Coli.

• Host Species
• Mouse

• Type
• Mouse IgG1

• Specificity
• Human RB1CC1

• Species Reactivity
• Human

• Clone
• 2C9A11

• Molecule Class
• Tumor Suppressor

• Applications
• WB, ELSIA

• Conjugate
• Unconjugated

• Related Disease
• Tumor suppressor

• Clonality
• Monoclonal

• Purity
• >95% as determined by SDS-PAGE and SEC-HPLC analysis

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• 0.05% sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Western Blot: 1:500 - 1:2000
  Enzyme-linked Immunosorbent Assay: 1:10000

• Alternative Names
• RB1CC1; Phosphatase 1, Regulatory Subunit 131; PPP1R131; 200 KDa FAK Family Kinase-Interacting Protein; RB1-Inducible Coiled-Coil 1; Regulatory Subunit 131; RB1-Inducible Coiled-Coil Protein 1; FAK Family Kinase-Interacting Protein Of 200 KDa; KIAA0203; C

• Gene ID
• 9821

• UniProt ID
• Q8TDY2

• Long Name
• RB1 inducible coiled-coil 1

• Cellular Localization
• Cytoplasm; Lysosome; Nucleus

• Post Translation Modifications
• Phosphoprotein

• Protein Refseq
• NP_001077086.1

• Function
• Involved in autophagy (PubMed:21775823).; Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225).; Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity).; Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity).; Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124).; Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity).; Functions as a DNA-binding transcription factor (PubMed:12095676).; Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007).; Plays a crucial role in muscular differentiation (PubMed:12163359).; Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).

Isotype Control

• MOB-065CQ
• Mouse IgG1 Isotype Control Antibody

Secondary Antibody

• 2RD-A1562-YJ
• Rabbit Anti-Mouse IgG1 Secondary antibody (Clone RM106)

Reconstitution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

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