Mouse Anti-RB1CC1 Recombinant Antibody (clone 2C9A11)
CAT#: VS7-0425-WR768
This product is a mouse IgG1 antibody that binds to human RB1CC1. The antibody 2C9A11 recognizes specific amino acid domain of human RB1CC1 (AA: 148-244). It can be used for WB and ELISA assays.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53049/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows cytoplasmic positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24391/126038_A_5_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53049/126015_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53049/126015_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53049/126015_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53049/126015_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000023287-RB1CC1
❮
❯
Specifications
- Immunogen
- Recombinant human RB1CC1 (AA: 148-244) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human RB1CC1
- Species Reactivity
- Human
- Clone
- 2C9A11
- Molecule Class
- Tumor Suppressor
- Applications
- WB, ELSIA
- Conjugate
- Unconjugated
- Related Disease
- Tumor suppressor
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- RB1CC1; Phosphatase 1, Regulatory Subunit 131; PPP1R131; 200 KDa FAK Family Kinase-Interacting Protein; RB1-Inducible Coiled-Coil 1; Regulatory Subunit 131; RB1-Inducible Coiled-Coil Protein 1; FAK Family Kinase-Interacting Protein Of 200 KDa; KIAA0203; C
- Gene ID
- 9821
- UniProt ID
- Q8TDY2
- Long Name
- RB1 inducible coiled-coil 1
- Cellular Localization
- Cytoplasm; Lysosome; Nucleus
- Post Translation Modifications
- Phosphoprotein
- Protein Refseq
- NP_001077086.1
- Function
- Involved in autophagy (PubMed:21775823).; Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225).; Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity).; Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity).; Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124).; Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity).; Functions as a DNA-binding transcription factor (PubMed:12095676).; Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007).; Plays a crucial role in muscular differentiation (PubMed:12163359).; Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS7-0425-WR768. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "RB1CC1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3506z | Mouse Anti-RB1CC1 Recombinant Antibody (clone 40H11) | ELISA, WB, FuncS | Mouse IgG1 |
| VS3-CJ53 | Mouse Anti-RB1CC1 Recombinant Antibody (VS3-CJ53) | WB, ELISA | Mouse IgG |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Neut, ELISA, FuncS
-2.jpg)
Application: IB, ELISA, FC, FuncS
Application: Neut, ELISA, FuncS
Application: ELISA, Neut
Application: ELISA, Block, WB, FC, IP
Application: ELISA, Cyt, PP, Inhib
Application: Inhib, FC, WB
Application: ELISA, WB, IF, FC, IP
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
