Mouse Anti-RB1CC1 Recombinant Antibody (VS3-CJ53)
CAT#: VS3-CJ53
This product is a mouse antibody that recognizes RB1CC1.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53049/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows cytoplasmic positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24391/126038_A_5_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53049/126015_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53049/126015_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53049/126015_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53049/126015_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000023287-RB1CC1
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Specifications
- Immunogen
- Recombinant fragment of human RB1CC1 (N-terminus)
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human RB1CC1
- Species Reactivity
- Human
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- 1 mg/mL (lot specific)
- Buffer
- 50% Glycerol, 1% BSA, PBS, pH7.4.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in ELISA (1:5000-1:20000), Western Blot (1:100-1:2000).
Target
- Alternative Names
- ATG17; CC1; FIP200; PPP1R131
- Gene ID
- 9821
- UniProt ID
- Q8TDY2
- Sequence Similarities
- Belongs to the ATG17 family.
- Cellular Localization
- Nucleus, Cytoplasm, Lysosome
- Protein Refseq
- NP_001077086.1; NP_055596.3
- Function
- Involved in autophagy (PubMed:21775823).
Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225).
Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity).
Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity).
Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124).
Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity).
Functions as a DNA-binding transcription factor (PubMed:12095676).
Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007).
Plays a crucial role in muscular differentiation (PubMed:12163359).
Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
- CAT
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Recommended Dilution Buffer
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- Product Name
See other products for "RB1CC1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3506z | Mouse Anti-RB1CC1 Recombinant Antibody (clone 40H11) | ELISA, WB, FuncS | Mouse IgG1 |
| VS7-0425-WR768 | Mouse Anti-RB1CC1 Recombinant Antibody (clone 2C9A11) | WB, ELSIA | Mouse IgG1 |
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