Mouse Anti-RB1CC1 Recombinant Antibody (VS3-CJ53) (CAT#: VS3-CJ53)

• Immunogen
• Recombinant fragment of human RB1CC1 (N-terminus)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human RB1CC1

• Species Reactivity
• Human

• Applications
• WB, ELISA

• Conjugate
• Unconjugated

• Purification
• Protein G affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• 1 mg/mL (lot specific)

• Buffer
• 50% Glycerol, 1% BSA, PBS, pH7.4.

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• This antibody has been tested for use in ELISA (1:5000-1:20000), Western Blot (1:100-1:2000).

• Alternative Names
• ATG17; CC1; FIP200; PPP1R131

• Gene ID
• 9821

• UniProt ID
• Q8TDY2

• Sequence Similarities
• Belongs to the ATG17 family.

• Cellular Localization
• Nucleus, Cytoplasm, Lysosome

• Protein Refseq
• NP_001077086.1; NP_055596.3

• Function
• Involved in autophagy (PubMed:21775823).
  Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225).
  Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity).
  Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity).
  Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124).
  Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity).
  Functions as a DNA-binding transcription factor (PubMed:12095676).
  Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007).
  Plays a crucial role in muscular differentiation (PubMed:12163359).
  Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

• 2ND-042CQ
• Rabbit Anti-Mouse IgG (H&L) Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

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