Rabbit Anti-RNGTT Recombinant Antibody (VS13-YC1012) (CAT#: VS13-YC1012)
The Rabbit Anti-RNGTT Recombinant Antibody is specific for human and rat RNGTT. RNGTT encodes RNA guanylyltransferase involved in mRNA splicing, associated with diseases like lymphomatous meningitis, with a paralog DUSP11. The anti-RNGTT antibody can be used for Western blot (1/500-1/1000), Immunofluorescence (1/50-1/200), Immunoprecipitation (1/20).
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/if_selected.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/if_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong nuclear positivity in trophoblastic cells and decidual cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows strong nuclear positivity in trophoblastic cells and decidual cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/ihc_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/20063_B_7_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/20063_B_7_5.jpg
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/20063_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/20063_A_7_3.jpg
Figure 5 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/20063_A_9_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/20063_A_9_4.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/20063_A_5_6.jpg
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3750/20063_A_5_6.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111880-RNGTT
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111880-RNGTT
Specifications
- Immunogen
- Recombinant human HCE.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat RNGTT
- Species Reactivity
- Human, Rat
- Applications
- WB, ICC, IF, IP
- Conjugate
- NONE
- Related Disease
- Lymphomatous Meningitis and Cecum Adenocarcinoma
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunofluorescence (IF): 1/50-1/200
Immunoprecipitation (IP): 1/20
Target
- Alternative Names
- RNA Guanylyltransferase And 5'-Phosphatase; RNA Guanylyltransferase And 5-Phosphatase; HCAP1; CAP1A; HCE; MRNA-Capping Enzyme; HCAP; HCE1;
- Gene ID
- 8732
- UniProt ID
- O60942
- Long Name
- RNA Guanylyltransferase And 5'-Phosphatase
- Cellular Localization
- Nucleus
- Protein Refseq
- XP_047275398.1; XP_047275399.1; XP_054212620.1; XP_054212621.1; NP_001273355.1
- Function
- Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2806z | Mouse Anti-RNGTT Recombinant Antibody (clone 36G8) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| VS3-WK1316 | Mouse Anti-RNGTT Recombinant Antibody (VS3-WK1316) | ELISA, WB | Mouse IgG |
| VS3-FY1735 | Rabbit Anti-RNGTT Recombinant Antibody (clone R06-6B2) | WB, IP | Rabbit IgG |
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