Anti-RSPO2 Antibody Prodrug, Protease Activated (VS-1025-YC111)
CAT#: VS-1025-YC111
The Anti-RSPO2 Antibody Prodrug, Protease Activated (VS-1025-YC111) is an antibody prodrug comprised of a recombinant human antibody targeting human RSPO1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to RSPO2 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to RSPO2 effectively. RSPO1 (R-spondin 1) is a secreted protein that acts as a potent agonist of the Wnt signaling pathway, which is central to cell proliferation and maintenance of cancer stem cells. It functions by stabilizing Wnt receptors on the cell surface, leading to enhanced Wnt beta-catenin signaling. While not frequently mutated, its overexpression in the tumor microenvironment is strongly associated with promoting the growth and survival of various tumors, including colorectal and ovarian cancers.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human ovary
Immunohistochemical staining of human ovary shows strong positivity in follicle cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24764/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human esophagus
Immunohistochemical staining of human esophagus shows cytoplasmic positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53068/123521_B_4_1_selected.jpg
Normal Tissue
Figure 3 IHC staining of human liver
Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25900/ihc_selected.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24764/61238_A_8_8.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24764/61238_A_9_5.jpg
Normal Tissue
Figure 6 Placenta
Decidual cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Trophoblastic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25900/61111_A_2_7.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HEK93, U-266/70)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000147655-RSPO2
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Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human RSPO1
- Target
- RSPO2
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- RSPO2 (R-Spondin 2) is a Protein Coding gene. Diseases associated with RSPO2 include Humerofemoral Hypoplasia With Radiotibial Ray Deficiency and Tetraamelia Syndrome 2. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and G protein-coupled receptor binding.
- Alternative Names
- RSPO2, CRISTIN2, R-spondin 2
- Gene ID
- 340419
- UniProt ID
- Q6UXX9
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Datasheet
MSDS
COA
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See other products for "RSPO2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0226CL | Mouse Anti-RSPO2 Recombinant Antibody (TAB-0226CL) | ELISA, Inhib, Block, FuncS, In vivo |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0227CL | Mouse Anti-RSPO2 Recombinant Antibody (TAB-0227CL) | ELISA, Inhib, Block, FuncS, In vivo |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0228CL | Mouse Anti-RSPO2 Recombinant Antibody (TAB-0228CL) | ELISA, Inhib, Block, FuncS, In vivo |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0229CL | Mouse Anti-RSPO2 Recombinant Antibody (TAB-0229CL) | ELISA, Inhib, Block, FuncS, In vivo |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0230CL | Mouse Anti-RSPO2 Recombinant Antibody (TAB-0230CL) | ELISA, Inhib, Block, FuncS, In vivo |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0232CL | Human Anti-RSPO2 Recombinant Antibody (TAB-0232CL) | ELISA, Inhib, Block, FuncS, In vivo | Humanized Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0233CL | Human Anti-RSPO2 Recombinant Antibody (TAB-0233CL) | ELISA, Inhib, Block, FuncS, In vivo | Humanized Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0232CL-S(P) | Human Anti-RSPO2 Recombinant Antibody scFv Fragment (TAB-0232CL-S(P)) | ELISA, Inhib, Block, FuncS, In vivo | Humanized Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0233CL-S(P) | Human Anti-RSPO2 Recombinant Antibody scFv Fragment (TAB-0233CL-S(P)) | ELISA, Inhib, Block, FuncS, In vivo | Humanized Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0232CL-F(E) | Human Anti-RSPO2 Recombinant Antibody Fab Fragment (TAB-0232CL-F(E)) | ELISA, Inhib, Block, FuncS, In vivo | Humanized Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1923CQ | Recombinant Rat Anti-RSPO2 Antibody (CBL669) | Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0307-WJ | Human Anti-RSPO2 Recombinant Antibody (HPAB-0307-WJ) | ELISA, FC, Block, Inhib, FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0307-WJ-S(P) | Human Anti-RSPO2 Recombinant Antibody; scFv Fragment (HPAB-0307-WJ-S(P)) | ELISA, FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0307-WJ-F(E) | Human Anti-RSPO2 Recombinant Antibody; Fab Fragment (HPAB-0307-WJ-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0224-XY106 | Mouse Anti-RSPO2 Recombinant Antibody (VS-0224-XY106) | WB, IHC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6252 | Anti-RSPO2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC281 | Recombinant Anti-RSPO2 Eliminating Antibody, pH-Sensitive (VS-0625-YC281) | Antigen-Sweeping In Vivo. | Human IgG |
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