Recombinant Alpaca Anti-RTA Single Domain Antibody (V5E1) (CAT#: PABC-570)

This product is a recombinant Alpaca antibody that can recognize RTA. V5E1 binds an epitope associated with stronger neutralizing activity.


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Neut

Figure 1 Alpaca Anti-RTA Single Domain Antibody (V5E1) in Neut.

Figure 1 Alpaca Anti-RTA Single Domain Antibody (V5E1) in Neut.

Relationship between V5E1 competition and toxin-neutralizing activity. Linear regression analysis of IC50s of Tier I and Tier II VHHs versus competition (% inhibition) with V5E1 (n = 8; r 2 = 0.8475; p = 0.0012). Tier III VHHs were not included in this analysis since they did not produce quantifiable IC50s. Each point on the graph represents a VHH. IC50 values are the mean of at least three technical replicates, while % inhibition values are the mean and SD of three technical replicates.

Amanda, P. , David, V. , Rong, Y. , Dylan, E. , & Nicholas, M. . (2017). A supercluster of neutralizing epitopes at the interface of ricin's enzymatic (rta) and binding (rtb) subunits. Toxins, 9(12), 378.


Specifications

  • Host Species
  • Alpaca
  • Type
  • Alpaca VHH
  • Specificity
  • RTA
  • Species Reactivity
  • Castor bean
  • Clone
  • V5E1
  • Applications
  • ELISA, FC, Neut

Product Property

  • Purity
  • >95% as determined by analysis by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Target

  • Alternative Names
  • Ricin A chain; Ricin; RTA; Ricinus communis

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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