Rabbit Anti-RUVBL2 Recombinant Antibody (clone R05-8F9)
CAT#: VS3-XY3492
It is a recombinant rabbit antibody specific for RUVBL2 (RuvB like AAA ATPase 2), which plays an essential role in oncogenic transformation by MYC. The antibody specifically reacts with human and mouse RUVBL2. This product has been reported for use in Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42880/736_G2_3_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm, cytosol & centrosome.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67966/1718_F2_19_cr57f3d591e8263_selected.jpg
Normal Tissue
Figure 3 Testis
Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67966/161986_A_4_6.jpg
RNA Expression
Figure 4 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183207-RUVBL2
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse RUVBL2
- Species Reactivity
- Human, Mouse
- Clone
- R05-8F9
- Applications
- WB
- Related Disease
- Hemangioma of Spleen; Distal Spinal Muscular Atrophy 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- RVB2; TIH2; ECP51; TIP48; CGI-46; ECP-51; INO80J; REPTIN; TIP49B; TAP54-beta
- Gene ID
- 10856
- UniProt ID
- Q9Y230
- Long Name
- RuvB like AAA ATPase 2
- Cellular Localization
- Nucleus, nucleoplasm, Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys9, Lys164, Lys177, Lys197, Lys223, Lys234, Lys269, Lys365, Lys368, Lys417, Lys427, Lys444, and Lys456 (NX_Q9Y230 [NX_Q9Y230-1])
Modification sites at PhosphoSitePlus (Q9Y230)
Glycosylation from GlyGen (Q9Y230) 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- NP_001308120.1; NP_001308119.1
- Function
- Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, 17157868, 33205750).
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "RUVBL2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2874z | Mouse Anti-RUVBL2 Recombinant Antibody (clone 6B6) | WB, FC, IF, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3146 | Hi-Affi™ Recombinant Rabbit Anti-RUVBL2 Monoclonal Antibody (DS3146AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY458 | Mouse Anti-NHP RUVBL2 Recombinant Antibody (clone OTI1A6) | WB, IHC, IF, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1981 | Anti-RUVBL2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6281 | Anti-Human RUVBL2 Immunohistochemistry Kit | IHC |
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