Rabbit Anti-RUVBL2 Recombinant Antibody (clone R05-8F9) (CAT#: VS3-XY3492)
It is a recombinant rabbit antibody specific for RUVBL2 (RuvB like AAA ATPase 2), which plays an essential role in oncogenic transformation by MYC. The antibody specifically reacts with human and mouse RUVBL2. This product has been reported for use in Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42880/736_G2_3_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42880/736_G2_3_selected.jpg
Figure 2 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm, cytosol & centrosome.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67966/1718_F2_19_cr57f3d591e8263_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm, cytosol & centrosome.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67966/1718_F2_19_cr57f3d591e8263_selected.jpg
Figure 3 Testis
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67966/161986_A_4_6.jpg
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67966/161986_A_4_6.jpg
Figure 4 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183207-RUVBL2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183207-RUVBL2
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse RUVBL2
- Species Reactivity
- Human, Mouse
- Clone
- R05-8F9
- Applications
- WB
- Related Disease
- Hemangioma of Spleen; Distal Spinal Muscular Atrophy 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- RVB2; TIH2; ECP51; TIP48; CGI-46; ECP-51; INO80J; REPTIN; TIP49B; TAP54-beta
- Gene ID
- 10856
- UniProt ID
- Q9Y230
- Long Name
- RuvB like AAA ATPase 2
- Cellular Localization
- Nucleus, nucleoplasm, Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys9, Lys164, Lys177, Lys197, Lys223, Lys234, Lys269, Lys365, Lys368, Lys417, Lys427, Lys444, and Lys456 (NX_Q9Y230 [NX_Q9Y230-1])
Modification sites at PhosphoSitePlus (Q9Y230)
Glycosylation from GlyGen (Q9Y230) 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- NP_001308120.1; NP_001308119.1
- Function
- Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, 17157868, 33205750).
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2874z | Mouse Anti-RUVBL2 Recombinant Antibody (clone 6B6) | WB, FC, IF, IHC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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