Anti-S100A10 (clone W24V125) Recombinant Antibody Coupled Liposome (VS-1024-FY127)
CAT#: VS-1024-FY127
Anti-S100A10 antibodies that are bound to liposomes represent a promising strategy in glioma research, as they can specifically target tumor cells while minimizing off-target effects. S100A10 is believed to play a crucial role in the regulation of immune responses within the glioma microenvironment, thus influencing tumor growth and progression. By utilizing liposomes as a drug delivery system, the therapeutic efficacy of these antibodies may be significantly enhanced, allowing for sustained release and improved bioavailability at the tumor site. This innovative approach could not only advance our understanding of glioma biology but also pave the way for more effective treatment modalities in combating this challenging form of brain cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3340/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25484/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3340/163925_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Microvilli Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75% Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3340/163925_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3340/163925_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3340/163925_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (OE19)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197747-S100A10
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V125
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that exhibits a high specificity for human S100A10, a protein involved in various cellular processes. The unique design of this antibody allows for precise targeting and binding to S100A10, which is crucial for studying its role in health and disease. Researchers can utilize this antibody in various applications, including diagnostic assays and therapeutic development, to explore the implications of S100A10 in different biological contexts.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- S100A10
- Introduction
- The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis.
- Alternative Names
- S100 Calcium Binding Protein A10; S100 Calcium Binding Protein A10 (Annexin II Ligand, Calpactin I, Light Polypeptide (P11)); Annexin II Tetramer (AIIt) P11 Subunit; Cellular Ligand Of Annexin II; Calpactin I Light Chain; Calpactin-1 Light Chain; ANX2LG; CAL1L; CLP11; P11; S100 Calcium-Binding Protein A10 (Annexin II Ligand, Calpactin I, Light Polypeptide (P11))
- Full Name
- S100 Calcium Binding Protein A10
- Gene ID
- 6281
- UniProt ID
- P60903
- Sequence Similarities
- Belongs to the S-100 family.
- Post Translation Modifications
- Ubiquitination at Lys18, Lys37, Lys47, Lys54, and Lys57 ( NX_P60903 [NX_P60903-1] )
Modification sites at PhosphoSitePlus ( P60903 )
Glycosylation from GlyGen (P60903) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_002957.1
- Function
- Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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