Mouse Anti-S100B Recombinant Antibody (clone ABT-S100B) (CAT#: VS3-CJ346)

• Immunogen
• Synthesized peptide derived from human S100

• Host Species
• Mouse

• Type
• Mouse IgG1, κ

• Specificity
• Human S100B

• Species Reactivity
• Human

• Clone
• ABT-S100B

• Applications
• IHC-P

• Conjugate
• Unconjugated

• Purification
• Affinity chromatography

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 50% Glycerol, 0.5% BSA, PBS.

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• This antibody has been tested for use in Immunohistochemistry-Parraffin (1:100-1:500).

• Alternative Names
• Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B

• Gene ID
• 6285

• UniProt ID
• P04271

• Sequence Similarities
• Belongs to the S-100 family.

• Cellular Localization
• Cytoplasm, Nucleus

• Protein Refseq
• NP_006263.1

• Function
• Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS