CytoStream™ Rabbit Anti-SATB2 Recombinant Antibody (VS13-YC1038) (CAT#: VS13-YC1038)

• Immunogen
• Recombinant human SATB2, aa 238-287.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat SATB2

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, ICC, IF, IHC-P, FC

• Conjugate
• NONE

• Related Disease
• Glass Syndrome and Cleft Palate, Isolated

• Clonality
• Monoclonal

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.

• Preservative
• 0.05% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/500-1/1000
  Immunofluorescence (IF-cell): 1/50-1/100
  Immunofluorescence (IF-tissue): 1/50-1/100
  Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
  Flow cytometry (FC): 1/50-1/100

• Alternative Names
• SATB Homeobox 2; Special AT-Rich Sequence-Binding Protein 2; SATB Family Member 2; DNA-Binding Protein SATB2; KIAA1034; GLSS;

• Gene ID
• 23314

• UniProt ID
• Q9UPW6

• Long Name
• SATB Homeobox 2

• Sequence Similarities
• Belongs to the CUT homeobox family.

• Cellular Localization
• Nucleus

• Protein Refseq
• NP_001165980.1; NP_001165988.1; NP_056080.1

• Function
• Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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