CytoStream™ Rabbit Anti-SATB2 Recombinant Antibody (VS13-YC1038)
CAT#: VS13-YC1038
The CytoStream™ Rabbit Anti-SATB2 Recombinant Antibody is specific for human, mouse and rat SATB2. SATB2 encodes a DNA binding protein linking to defects like cleft palate and cognitive impairments, functioning in transcription and chromatin remodeling. The anti-SATB2 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29543/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_A_9_3.jpg
Normal Tissue
Figure 4 Rectum
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_A_4_3.jpg
Normal Tissue
Figure 5 Kidney
Proximal tubules (cell body)
Staining: Low
Intensity: Moderate
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HEL, K-562, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119042-SATB2/subcellular
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Specifications
- Immunogen
- Recombinant human SATB2, aa 238-287.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat SATB2
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, IF, IHC-P, FC
- Conjugate
- NONE
- Related Disease
- Glass Syndrome and Cleft Palate, Isolated
Product Property
- Clonality
- Monoclonal
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunofluorescence (IF-cell): 1/50-1/100
Immunofluorescence (IF-tissue): 1/50-1/100
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- SATB Homeobox 2; Special AT-Rich Sequence-Binding Protein 2; SATB Family Member 2; DNA-Binding Protein SATB2; KIAA1034; GLSS;
- Gene ID
- 23314
- UniProt ID
- Q9UPW6
- Long Name
- SATB Homeobox 2
- Sequence Similarities
- Belongs to the CUT homeobox family.
- Cellular Localization
- Nucleus
- Protein Refseq
- NP_001165980.1; NP_001165988.1; NP_056080.1
- Function
- Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "SATB2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-888 | Recombinant Anti-human SATB2 Antibody | WB, ELISA, IHC, FuncS | IgG |
| MRO-1366-CN | Recombinant Rabbit Anti-SATB2 Monoclonal Antibody (JM52-44) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-QX1000 | Mouse Anti-SATB2 Recombinant Antibody (clone 4G03) | WB, IP, IF | Mouse IgG1 |
| VS3-FY1624 | Rabbit Anti-SATB2 Recombinant Antibody (clone R02-1H5) | WB | Rabbit IgG |
| VS3-XY3494 | Rabbit Anti-SATB2 Recombinant Antibody (clone R06-6D8) | WB, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-888-F(E) | Recombinant Anti-human SATB2 Antibody Fab Fragment | ELISA, WB, FuncS | Fab |
| MHH-888-F(E) | Recombinant Human Anti-human SATB2 Antibody Fab Fragment | IP, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-888-S(P) | Recombinant Anti-human SATB2 Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| MHH-888-S(P) | Recombinant Human Anti-human SATB2 Antibody scFv Fragment | WB, FC, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3175 | Hi-Affi™ Recombinant Rabbit Anti-SATB2 Monoclonal Antibody (DS3175AB) | WB, IP, IHC-P, ICC, IF, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6356 | Anti-SATB2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6357 | Anti-Mouse SATB2 Immunohistochemistry Kit | IHC |
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