Mouse Anti-SERPINC1 Recombinant Antibody (VS3-FY2869) (CAT#: VS3-FY2869)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human, Rat SERPINC1

• Species Reactivity
• Human, Rat

• Applications
• Western Blot

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 52.6 kDa.

• Related Disease
• Antithrombin Iii Deficiency and Thrombosis

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/100-1/1600

• Alternative Names
• Serpin Family C Member 1; Serine (Or Cysteine) Proteinase Inhibitor, Clade C (Antithrombin), Member 1; Serpin Peptidase Inhibitor, Clade C (Antithrombin), Member 1; ATIII; AT3; Coding Sequence Signal Peptide Antithrombin Part 1; Serpin Peptidase Inhibitor Clade C Member 1; Signal Peptide Antithrombin Part 1

• Gene ID
• 462

• UniProt ID
• P01008

• Sequence Similarities
• Belongs to the serpin family.

• Cellular Localization
• Secreted, extracellular space

• Post Translation Modifications
• Phosphorylated by FAM20C in the extracellular medium. (P01008-ANT3_HUMAN)
  Glycosylation at Asn128, Asn167, Asn187, and Asn224 (NX_P01008 [NX_P01008-1])
  Modification sites at PhosphoSitePlus (P01008)
  Glycosylation from GlyConnect ANT3_HUMAN (766)
  Glycosylation from GlyGen (P01008) 7 sites, 25 N-linked glycans (4 sites), 2 O-linked glycans (1 site)

• Protein Refseq
• NP_001351981.1; NP_001373231.1; NP_001373232.1; NP_001373233.1

• Function
• Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15853774, 15140129).
  AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129).
  Its inhibitory activity is greatly enhanced in the presence of heparin.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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