Rabbit Anti-SETD7 Recombinant Antibody (clone R05-3B6) (CAT#: VS3-XY3502)
The recombinant rabbit antibody reacts with SETD7 (SET domain containing 7, histone lysine methyltransferase), which plays a central role in the transcriptional activation of genes. This antibody specifically reacts with human, mouse and rat SETD7. It has been tested using Western Blot and Immunoprecipitation. The recommended dilutions of Western Blot and Immunoprecipitation is 1/500-1/1000 and 1/20.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoli.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1039_D5_2_red_green.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoli.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1039_D5_2_red_green.jpg
Figure 2 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli rim & mitotic chromosome.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1147_A6_1_red_green.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli rim & mitotic chromosome.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1147_A6_1_red_green.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli rim.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1037_D5_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli rim.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1037_D5_1_red_green.jpg
Figure 4 Esophagus
(Squamous epithelial cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_B_5_1.jpg
(Squamous epithelial cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_B_5_1.jpg
Figure 5 Colon
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_A_9_3.jpg
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_A_9_3.jpg
Figure 6 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_A_8_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_A_8_8.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145391-SETD7
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145391-SETD7
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat SETD7
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-3B6
- Applications
- WB, IP
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IP: 1/20
Target
- Alternative Names
- KMT7; SET7; SET9; SET7/9
- Gene ID
- 80854
- UniProt ID
- Q8WTS6
- Long Name
- SET domain containing 7, histone lysine methyltransferase
- Cellular Localization
- Nucleus, Chromosome
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (Q8WTS6)
Modification sites at neXtProt (NX_Q8WTS6)
Glycosylation from GlyGen (Q8WTS6) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054206895.1; XP_016864150.1
- Function
- Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, 11850410, 12588998, 12540855, 16141209).
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12588998, 12540855, 16141209).
Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:16141209, 12588998).
Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209).
Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-525 | Recombinant Human Anti-Human SETD7 Antibody, clone D283 | IF, ELISA, IP-MS | IgG |
| MOB-1875CT | Recombinant Mouse anti-Human SETD7 Monoclonal antibody (t5F6) | ChIP, ELISA, FC, ICC/IF, IHC-G, IHC-P, WB | |
| VS11-QX128 | Human Anti-SETD7 Recombinant Antibody (clone RAB-C220) | ELISA, IF, IP, ChIP, FC | Human IgG1, κ |
| VS7-0425-WR847 | Mouse Anti-SETD7 Recombinant Antibody (clone 1B3B8) | WB, FC | Mouse IgG2a |
| VS7-0425-WR848 | Mouse Anti-SETD7 Recombinant Antibody (clone 3D6G11) | WB, IHC | Mouse IgG1 |
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