Human Anti-SETD7 Recombinant Antibody (clone RAB-C220) (CAT#: VS11-QX128)
This product is a recombinant human antibody that recognizes SETD7. This antibody can be used for the following applications: ELISA, IF, IP, IP-MS, ChIP, FC.
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Custom Production
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoli.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1039_D5_2_red_green.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoli.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1039_D5_2_red_green.jpg
Figure 2 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli rim & mitotic chromosome.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1147_A6_1_red_green.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli rim & mitotic chromosome.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1147_A6_1_red_green.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli rim.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1037_D5_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli rim.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/1037_D5_1_red_green.jpg
Figure 4 Esophagus
(Squamous epithelial cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_B_5_1.jpg
(Squamous epithelial cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_B_5_1.jpg
Figure 5 Colon
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_A_9_3.jpg
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_A_9_3.jpg
Figure 6 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_A_8_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58111/131814_A_8_8.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145391-SETD7
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145391-SETD7
Specifications
- Immunogen
- SETD7 protein
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG1, κ
- Specificity
- Human SETD7
- Species Reactivity
- Human
- Clone
- RAB-C220
- Applications
- ELISA, IF, IP, ChIP, FC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- 1 mg/mL (Please refer to the vial label for the specific concentration.)
- Buffer
- 0.2 μm filtered solution in PBS
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipped at 4°C.
Target
- Alternative Names
- KMT7; SET7; SET9; SET7/9
- Gene ID
- 80854
- UniProt ID
- Q8WTS6
- Long Name
- Histone-lysine N-methyltransferase SETD7
- Sequence Similarities
- Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
- Cellular Localization
- Nucleoli, Nucleoli rim, Mitotic chromosome
- Function
- Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-525 | Recombinant Human Anti-Human SETD7 Antibody, clone D283 | IF, ELISA, IP-MS | IgG |
| MOB-1875CT | Recombinant Mouse anti-Human SETD7 Monoclonal antibody (t5F6) | ChIP, ELISA, FC, ICC/IF, IHC-G, IHC-P, WB | |
| VS3-XY3502 | Rabbit Anti-SETD7 Recombinant Antibody (clone R05-3B6) | WB, IP | Rabbit IgG |
| VS7-0425-WR847 | Mouse Anti-SETD7 Recombinant Antibody (clone 1B3B8) | WB, FC | Mouse IgG2a |
| VS7-0425-WR848 | Mouse Anti-SETD7 Recombinant Antibody (clone 3D6G11) | WB, IHC | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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