Mouse Anti-SLC10A1 Recombinant Antibody (clone YN69083) (CAT#: VS-0624-FY33)
This mouse recombinant monoclonal antibody illustrates a strong affinity for the human SLC10A1 protein, originating from a hybridoma cell line.
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Normal Tissue
Figure 1 IHC staining of human liver
(Immunohistochemical staining of human liver shows membrane positivity in hepatocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42727/ihc_selected.jpg
(Immunohistochemical staining of human liver shows membrane positivity in hepatocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42727/ihc_selected.jpg
Figure 2 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42727/95206_B_7_5.jpg
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42727/95206_B_7_5.jpg
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42727/95206_A_8_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42727/95206_A_8_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42727/95206_A_7_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42727/95206_A_7_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42727/95206_A_9_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42727/95206_A_9_5.jpg
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human SLC10A1
- Species Reactivity
- Human
- Clone
- YN69083
- Applications
- Immunoassay
- Related Disease
- Hypercholanemia, Familial, 2 and Familial Hypercholanemia
Product Property
- Clonality
- Monoclonal Antibody
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Solute Carrier Family 10 Member 1; Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 1; Sodium/Taurocholate Cotransporting Polypeptide; Cell Growth-Inhibiting Gene 29 Protein; Na(+)/Taurocholate Transport Protein; Na(+)/Bile Acid Cotransporter; NTCP
- Gene ID
- 6554
- UniProt ID
- Q14973
- Long Name
- Solute Carrier Family 10 Member 1
- Sequence Similarities
- Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn5, Asn11, Asn117, and Asn336 (NX_Q14973 [NX_Q14973-1])
Modification sites at PhosphoSitePlus (Q14973)
Glycosylation from GlyGen (Q14973) 4 sites
- Protein Refseq
- NP_003040.1
- Function
- It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, 34060352).
Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3936z | Mouse Anti-SLC10A1 Recombinant Antibody (clone 43H2) | WB, IHC, FC | Mouse IgG1, κ |
Customer Reviews and Q&As
Customer Review
User 193*****26
Suitable for WB
Suitable for WB
I used this antibody in our lab for western blot. It gave nice clear bands at 1:500.
22.Jul,23
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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