Anti-SLC2A1 (clone W24V48) Recombinant Antibody Coupled Liposome (VS-1024-FY51)
CAT#: VS-1024-FY51
Anti-GLUT1 antibody-conjugated liposomes represent a targeted approach for delivering therapeutics across the blood-brain barrier (BBB). The BBB is a specialized endothelial barrier that protects the brain from potentially harmful substances in the bloodstream but also poses a significant challenge for drug delivery.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31345/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58494/if_selected.jpg
Normal Tissue
Figure 3 High expression in placenta
Trophoblastic cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31345/116018_A_2_7.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58494/133001_B_9_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (BEWO, CACO-2, Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000117394-SLC2A1
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More Infomation
Specifications
- Potential Clinical Applications
- Traversing the blood-brain barrier (BBB)
Product Composition
- Clone
- W24V48
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant antibody derived from mouse sources, specifically designed to target the glucose transporter 1 (GLUT1) protein. GLUT1 plays a crucial role in facilitating the transport of glucose across the plasma membranes of cells, which is essential for maintaining cellular energy levels and overall metabolic function.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- SLC2A1
- Introduction
- Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, promotes glucose transporter member 1 (SLC2A1), which is a single transporter encoded by the SLC2A1 gene in humans. GLUT1 promotes the transport of glucose across the plasma membrane of mammalian cells. This gene encodes the major glucose transporter in the mammalian blood-brain barrier. The encoded protein is mainly present on the cell membrane and cell surface, where it can also be used as a receptor for human T-cell leukemia virus (HTLV) I and II. One of the good sources of GLUT1 is the red blood cell membrane. GLUT1 accounts for 2 of erythrocyte plasma membrane protein. GLUT1 found in the plasma membrane of red blood cells is a classic example of a unidirectional transporter. After being transported into red blood cells, glucose is rapidly phosphorylated to form glucose-6-phosphate, which cannot leave the cells. Mutations in this gene can lead to GLUT1 deficiency 1, GLUT1 deficiency 2, idiopathic generalized epilepsy 12, dystonia 9 and gastrin deficiency.
- Alternative Names
- DYT17; DYT18; DYT18DYT17; DYT9; EIG12; Glucose transporter type 1; erythrocyte brain; Glut1; GLUT-1; GLUT1DS; GLUT1GLUT; HepG2 glucose transporter; MGC141895; MGC141896; PED; SLC2A1; solute carrier family 2 (facilitated glucose transporter); member 1; solute carrier family 2; facilitated glucose transporter member 1
- Full Name
- Glucose Transporter Type 1
- Gene ID
- 6513
- Sequence Similarities
- Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization.
- Protein Refseq
- NP_006507.2
- Function
- Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:10227690).
Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892).
Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690).
In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
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Datasheet
MSDS
COA
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