Rabbit Anti-SLC4A1 Recombinant Antibody (clone R07-8A4) (CAT#: VS3-FY1662)
Clone R07-8A4 is a rabbit IgG recombinant antibody that has a high affinity for human SLC4A1 protein, a calculated weight of 102 kDa. It cross-reacts with mouse.
The following recommendations serve as a starting point for assay optimization. The actual working concentration may vary and should be determined by the user. The R07-8A4 is recommended for detection of target protein by western blotting (dilution range 1:500-1:1000).
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Normal Tissue
RNA Expression
Figure 1 Bone marrow
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_B_4_4_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_B_4_4_val_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_B_7_5.jpg
(Neuronal cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_B_7_5.jpg
Figure 3 Kidney
(Distal tubules Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_A_8_5.jpg
(Distal tubules Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_A_8_5.jpg
Figure 4 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_A_5_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_A_5_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (K-562)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000004939-SLC4A1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000004939-SLC4A1
Specifications
- Immunogen
- Synthetic peptides of human Band 3
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse SLC4A1
- Species Reactivity
- Human, Mouse
- Clone
- R07-8A4
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 102 kDa, while the observed molecular weight stands at 102 kDa.
- Related Disease
- Destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Solute Carrier Family 4 Member 1 (Diego Blood Group); Solute Carrier Family 4, Anion Exchanger, Member 1 (Erythrocyte Membrane Protein Band 3, Diego Blood Group); Solute Carrier Family 4 (Anion Exchanger), Member 1 (Diego Blood Group); Erythrocyte Membrane Protein Band 3; Anion Exchange Protein 1; Waldner Blood Group; Froese Blood Group; Wright Blood Group; Swann Blood Group; Diego Blood Group; EPB3; AE1; DI; Solute Carrier Family 4 (Anion Exchanger), Member 1; Solute Carrier Family 4, Anion Exchanger, Number 1; Erythroid Anion Exchange Protein; Solute Carrier Family 4 Member 1; Band 3 Anion Transport Protein
- Gene ID
- 6521
- UniProt ID
- P02730
- Sequence Similarities
- Belongs to the anion exchanger (TC 2.A.31) family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation., Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation., N-glycosylated.
- Protein Refseq
- NP_000333.1
- Function
- Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
(Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-335 | Mouse Anti-SLC4A1 Recombinant Antibody (clone CBL17Q); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| FAMAB-0302CQ-S(P) | Mouse Anti-SLC4A1 Recombinant Antibody (clone BIII.136); scFv Fragment | IP, WB, IF, ELISA | Mouse scFv |
| PSBS-0004 | Mouse Anti-SLC4A1 Recombinant Antibody (Clone 4201); scFv Fragment | ELISA, FuncS | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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