Human Anti-SLCO1B1 Recombinant Antibody (clone mab18)
CAT#: VS-0724-FY33
This is a human antibody that binds to human SLCO1B1. It binds to the extracellular side of the transporter and interacts with the ECL3 fragment that is conserved in OATP1B3. The structures of human OATP1B1 binds to synthetic Fab fragments and functionally distinct states are shown using cryo-EM.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73093/1916_B6_14_cr5c9a124f20748_selected.jpg
Normal Tissue
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows moderate membranous positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50892/ihc_selected.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50892/113836_A_7_4.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (HeLa, NTERA-2, RPMI-8226, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134538-SLCO1B1
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human SLCO1B1
- Species Reactivity
- Human
- Clone
- mab18
- Applications
- Electron Microscopy
- Related Disease
- Hyperbilirubinemia, Rotor Type and Gilbert Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Solute Carrier Organic Anion Transporter Family Member 1B1; Solute Carrier Family 21 (Organic Anion Transporter), Member 6; Sodium-Independent Organic Anion-Transporting Polypeptide 2; Liver-Specific Organic Anion Transporter 1; SLC21A6; OATP1B1; OATP-2; OATP-C
- Gene ID
- 10599
- UniProt ID
- Q9Y6L6
- Long Name
- Solute Carrier Organic Anion Transporter Family Member 1B1
- Sequence Similarities
- Belongs to the organo anion transporter (TC 2.A.60) family.
- Cellular Localization
- Basolateral cell membrane
Basal cell membrane
- Post Translation Modifications
- Glycosylation at Asn130, Asn134, Asn432, Asn503, Asn516, and Asn617
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites
- Protein Refseq
- NP_006437.3
- Function
- Involved in the clearance of endogenous and exogenous substrates from the liver.
Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition.
May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable).
Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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Secondary Antibody
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- Product Name
See other products for "SLCO1B1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1494CT | Recombinant Mouse anti-Human SLCO1B1 Monoclonal antibody (FTM) | ICC, IF, IP |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6702 | Anti-SLCO1B1 Immunohistochemistry Kit | IHC |
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