Human Anti-SLCO1B1 Recombinant Antibody (clone mab18) (CAT#: VS-0724-FY33)
This is a human antibody that binds to human SLCO1B1. It binds to the extracellular side of the transporter and interacts with the ECL3 fragment that is conserved in OATP1B3. The structures of human OATP1B1 binds to synthetic Fab fragments and functionally distinct states are shown using cryo-EM.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73093/1916_B6_14_cr5c9a124f20748_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73093/1916_B6_14_cr5c9a124f20748_selected.jpg
Figure 2 IHC staining of human liver
(Immunohistochemical staining of human liver shows moderate membranous positivity in hepatocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50892/ihc_selected.jpg
(Immunohistochemical staining of human liver shows moderate membranous positivity in hepatocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50892/ihc_selected.jpg
Figure 3 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50892/113836_A_7_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50892/113836_A_7_4.jpg
Figure 4 RNA cell line category: Cell line enhanced (HeLa, NTERA-2, RPMI-8226, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134538-SLCO1B1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134538-SLCO1B1
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human SLCO1B1
- Species Reactivity
- Human
- Clone
- mab18
- Applications
- Electron Microscopy
- Related Disease
- Hyperbilirubinemia, Rotor Type and Gilbert Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Solute Carrier Organic Anion Transporter Family Member 1B1; Solute Carrier Family 21 (Organic Anion Transporter), Member 6; Sodium-Independent Organic Anion-Transporting Polypeptide 2; Liver-Specific Organic Anion Transporter 1; SLC21A6; OATP1B1; OATP-2; OATP-C
- Gene ID
- 10599
- UniProt ID
- Q9Y6L6
- Long Name
- Solute Carrier Organic Anion Transporter Family Member 1B1
- Sequence Similarities
- Belongs to the organo anion transporter (TC 2.A.60) family.
- Cellular Localization
- Basolateral cell membrane
Basal cell membrane
- Post Translation Modifications
- Glycosylation at Asn130, Asn134, Asn432, Asn503, Asn516, and Asn617
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites
- Protein Refseq
- NP_006437.3
- Function
- Involved in the clearance of endogenous and exogenous substrates from the liver.
Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition.
May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable).
Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1494CT | Recombinant Mouse anti-Human SLCO1B1 Monoclonal antibody (FTM) | ICC/IF, IP |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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